Kerala State Drug Formulary.pdf

Glucocorticoids
I :
C/I:
P/C :
A/E:
P/A:
Dose:
Severe renal disease due to SLE, vasculitis, crescentic
nephritis and severe acute interstitial nephritis with
renal failure, acute transplant rejection.
Peptic ulcer, acute psychosis, Cushing’s syndrome,
herpes simplex,. keratitis, infections, lactation.
Diabetes, pregnancy, seizure disorder. To be used by
specialist only.
Besides the usual steroid side effects, acute
hyperglycemia, hypokalemia, infections, and
convulsions are more frequently encountered. Bolus
injections may produce sudden cardiac death.
Injection methyl prednisolone sodium succinate and
methyl prednisolone acetate in aqueous solution. 500
mg 1 g vials.
10 to 40 mg/ kg/ day not exceeding 1000 mg is given
as IV infusion in 200 mL of 5% dextrose over a period
of 30 min and is repeated consecutively for 3 to 5
days. This is usually followed by oral prednisolone at
a dose of 1mg/ kg.
MONOCLONAL ANTIBODIES.
BASILIXUMAB
DACLIZUMAB
ALEMTUZUMAB.
IMMUNOSUPPRESSANT ANTIBODIES
THYMOGLOBULIN (Antithymocyte globulin)
I: To suppress acute allograft regection episodes
especially in steroid resistant cases
A/E: serum sickness and anaphylaxis
P/A: thymoglobulin (rabbit)inj.25 mg/vial
ATG 100 mg injection.
Dose: 1.5-2.5mg/kg/day - Thymoglobulin
ATG 200mg IV/day
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