Kerala State Drug Formulary.pdf

Cardiovascular Drugs
In the absence of contraindication ,in post MI cases atenolol given in
dose of 5 mg i.v. slowly helps to reduce arrhythmias and episodes of sudden
death .
Note: Being water soluble, it does not cross blood — brain
barrier. Therefore fatigue, nightmares and other CNS
side effects are less.
Cost: Tab 50 mg (14) Rs. 19.00 - 31.00
Bisoprolol
I: Hypertension, angina
C/I:P/C:A/E:D/I: Same as propranolol.
P/A: Tablet 5 mg
Dose : 5 mg daily.
Cost: Tab 5 mg (10) Rs. 82.00 · 83.00
Esmolol
Ultra short-acting betablocker for parenteral use, with a half life of
9 min.
I: Supra ventricular arrhythmias,preoperative
hypertension, tachycardia.
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C/I:
Severe hypotension, asthma, severe COPD, other
contraindication for betablockers use.
P/C : Hypotension, diabetes mellitus, renal impairment,
pregnancy
A/E : Confusion,redness or swelling at the site of injection,
reduction in peripheral circulation.
P/A: Injection 10 mL ampoule each mL contains 100 mg.
Dose: S.V.T 500 mcg / kg/ min for 4 min.Maintenence dose is
150 - 300 mcg/kg/rnin.
D/I: Concurrent use of phenytoin with IV esmolol produces
additive cardiac depressant effect, increases the risk
of bradycardia, AV block, hypotension. When given along
with calcium channel blockers IV cardiac failure may
be precipitated. Esmpolol may increase blood digoxin
levels.
Cost: Inj 100 mg/10 mL (10 mL) Rs. 48.00 - 50.00
Drugs with combined alpha and beta blocker effect