Kerala State Drug Formulary.pdf

Cardiovascular Drugs
154
P/C :
P/A:
Dose:
acidosis; severe peripheral arterial disease;
phaeochromocytoma (unless used with alpha-blocker)
Avoid abrupt withdrawal especially in ischaemic heart
disease;history of obstructive airway disease (use with
caution and monitor lung function—see also
contraindications above); pregnancy breastfeeding
first-degree atrioventricular block; liver function
deteriorates in portal hypertension; reduce dose in
renal impairment, diabetes mellitus (small decrease in
glucose tolerance, masking of symptoms of
hypoglycaemia).
Tablet: 50 mg; 100 mg.
Angina, by mouth, 50 mg once daily, increased if
necessary to 50 mg twice daily or 100 mg once daily
Myocardial infarction (early intervention within 12 hours), by
intravenous injection over 5 minutes, 5 mg, then by mouth 50 mg after 15
minutes,followed by 50 mg after 12 hours, then 100 mg daily
A/E: gastrointestinal disturbances (nausea, vomiting,
diarrhoea,constipation, abdominal cramp); fatigue;
bronchospasm; bradycardia, heart failure, conduction
disorders, hypotension; sleep disturbances, including
nightmares; depression, confusion; hypoglycaemia or
hyperglycaemia.
Cost: Oral 50mg(14 tab) Rs. 25/-;Inj 5mg(10ml)Rs 5/-
Other BetaBlockers-Metoprolol,Propranolol
CALCIUM-CHANNEL BLOCKERS
A long-acting dihydropyridine calcium channel blocker (such as
amlodipine) can be added to betablocker treatment if necessary for control
of moderate stable angina. For those in whom a beta-blocker is inappropriate,
verapamil may be given as an alternative to treat stable angina. Calciumchannel
blockers can also be used in patients with unstable angina with a
vasospastic origin, such as Prinzmetal angina, and in patients in whom
alterations in cardiac tone may influence the angina threshold
MISCELLANEOUS DRUGS USED IN TREATMENT OF ANGINA
Trimetazidine
It is an antianginal agent which acts by vasodilation and effects on
cardiac metabolism