Kerala State Drug Formulary.pdf

Antiparkinsonian Drugs
Ropinirole
I: Parkinson’s disease, either used alone or as an adjunct
to levodopa.
C/I : Pregnancy and breast-feeding.
P/C : Hepatic impairment, renal impairment; severe
cardiovascular disease, major psychotic disorders, avoid
abrupt withdrawal.
A/E: Nausea, drowsiness, leg edema, abdominal pain,
vomiting and syncope; dyskinesia, hallucinations and
confusion reported in adjunctive therapy; occasionally
severe hypotension and bradycardia.
P/A: Tablets, 0.25mg, 0.5mg, 1mg, 2mg
Dose: Oral, initially 750mcg daily in 3 divided doses, increased
by increments of 750mcg at weekly intervals to 3mg
daily; further increased by increments of upto 3mg at
weekly intervals according to response; usual range 3-
9mg daily; maximum 24mg daily.
Cost: Tab 0.25mg (10) Rs 16.00
Tab 0.5mg (10) Rs 23.50 - 27.00
Tab 1mg (10) Rs 44.50 - 47.50
Tab 2mg (10) Rs 76.00 - 86.50
Pramipexole
I: Parkinson disease either alone or as an adjunct to
levodopa therapy to reduce the end of dose or on-off
fluctuations in response. Moderate to severe restless
leg syndrome.
P/C: Used with caution in patients with renal impairment
and regular ophthalmologic monitoring for visual
impairment.
A/E: GI disturbances, headache, dizziness, postural
hypotension, drowsiness, vasospasm of fingers and toes
particularly in-patients with Raynaud’s syndrome,
pathological gambling.
Dose: Initial dose 125mcg tds increased to 250 -500mcg tds
according to response to a maximum dose of 4.5mg
daily.
D/I: Sedating drugs and alcohol used with pramipexole leads
to additive effects and sudden onset of sleep.
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