Kerala State Drug Formulary.pdf

Macrolides
pertussis, endemic trachoma, legionellosis,
Campylobacter jejuni enteritis, acne, leptospirosis,
Lyme disease, endocarditis, prophylaxis before dental
procedure, community acquired pneumonia, relapsing
fever, tetanus in patients allergic to penicillin,
nocardiosis.
C/l: Hypersensitivity to erythromycin, history of jaundice.
P/C: Cholestatic hepatitis and history of hepatic disease,
pregnancy,lactation.
A/E: Gl upset,Rash, hepatitis
P/A: Available as Erythromycin estolate and Erythromycin
stearate.
Tablet 250 and 500 mg.
Capsules 250 mg
Ointment 2% w/w, 3% w/w
Gel 4% w/ w
Dose: 250-500 mg orally 6 th hourly
D/l: Increased risk of cardiotoxicity with increased plasma
concentration and toxicity of carbamazepine, valproic
acid, astemizole, terfenadine, cyclosporin, digoxin,
statins, theophylline, warfarin
Antagonises effect of chloramphenicol , lincomycin and
penicillins
Increased potential for ototoxicity with other ototoxic
medications in patients with renal impairment
Cost: Caps 250 mg (10) Rs. 40.00 - 42.00
Cream 3% w/w (20 g) Rs. 29.00 - 42.00
Oint 3% w/w (10 g) Rs. 15.00 - 16.00
Gel 4 % w/w (20 g) Rs. 37.00 - 41.00
Clarithromycin
I: Mycoplasma pneumoniae, mycobacterium leprae,
community acquired a typical pneumonia, atypical
mycobacterial infection, prophylaxis against MAC,
H. pylori, nocardiosis, upper and lower respiratory tract
infections, skin and soft tissue infections.
C/l :
Hypersensitivity. Patients on terfenadine or astemizole,
cardiac abnormality or electrolyte disturbance, safety
in pregnancy and lactating period is not established.
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