Kerala State Drug Formulary.pdf

Drugs for Induction of Labour
PROSTAGLANDINS
Misoprostol (PGE1)
Uterine stimulant
I: Cervical ripening, PPH, termination of pregnancy less
than 49 days.
C/I: Pregnancy, lactation
P/C: Hypotension, IBD, renal disease.
P/A: 25,50,100,2OO microgram
Cost: Tablet 200mcg,(4Tab) Rs 61/-
PGE2 gel (0.5mg)
This is administered intra cervically. It is relatively convenient and
effective method of induction of labour. But this drug should not be used
if there is a history of bronchial asthma.
Surgical method of induction
This is by a low rupture of membranes. Conditions to be satisfied:
Cervix should be partially effaced and at least 1 cm dilated. Presenting
part must be vertex and fixed at the brim of the pelvis.
INDUCTION OF ABORTION (MTP)
Upto 12 weeks
MIFEPRISTONE
Progesterone antagonist
I: MTP upto 49 days along with Misoprostol
C/I:
P/C:
A/E:
Dose:
Suspected ectopic, hypersensitivity, porphyria,
anticoagulant therapy, pregnancy, lactation.
Asthma, COPD, prosthetic heart valve
Anorexia, nausea, abdominal discomfort, loose stools,
uterine cramps
600mg single oral dose
Cost: Tablet 200mg 1Tab Rs 325/-
Surgical methods
Evacuation upto 6 weeks. This can be done using a menstrual
regulation syringe (Karman’s syringe) 6 — 8 weeks - Rapid dilatation using
metal dialator under para cervical block followed by suction evacuation. 8
- 12 weeks- 2 stage dialatation using laminaria tent is done. Then suction
evacuation is done.
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