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6 N.K. Dubey et al.Natural <strong>pest</strong> controls us<strong>in</strong>g botanicals are safer to the user and theenvironment because they break down <strong>in</strong>to harmless compounds with<strong>in</strong>hours or days <strong>in</strong> the presence of sunlight. Botanical <strong>pest</strong>icides are biodegradable(Devl<strong>in</strong> and Zettel, 1999) and their use <strong>in</strong> crop protection is a practicalsusta<strong>in</strong>able alternative. Pesticidal <strong>plant</strong>s have been <strong>in</strong> nature for millionsof years without any ill or adverse effects on the ecosystem. Botanical <strong>pest</strong>icidesare also very close chemically to those <strong>plant</strong>s from which they arederived, so they are easily decomposed by a variety of microbes common <strong>in</strong>most soils. Their use ma<strong>in</strong>ta<strong>in</strong>s the biological diversity of predators (Grangeand Ahmed, 1988), and reduces environmental contam<strong>in</strong>ation and humanhealth hazards. Botanical <strong>pest</strong>icides tend to have broad-spectrum activityand are sometimes stimulatory to the host metabolism (Mishra and Dubey,1994). Botanical <strong>in</strong>secticides can often be easily produced by farmers andsmall-scale <strong>in</strong>dustries. Recently, attention has been paid towards the exploitationof higher <strong>plant</strong> <strong>products</strong> as novel chemotherapeutics <strong>in</strong> <strong>plant</strong> protection.Such <strong>plant</strong> <strong>products</strong> have also been formulated for their large-scaleapplication <strong>in</strong> crop protection, and are regarded as pro-poor and cost-effective(Dubey et al., 2009).NeemNeem (Azadirachta <strong>in</strong>dica) is regarded as the ‘Wonder Tree’, ‘BotanicalMarvel’, ‘Gift of Nature’ and ‘Village Pharmacy’ <strong>in</strong> India. From prehistorictimes, neem has been used primarily aga<strong>in</strong>st household and storage <strong>pest</strong>s,and to some extent aga<strong>in</strong>st <strong>pest</strong>s related to field crops <strong>in</strong> the Indian subcont<strong>in</strong>ent.Neem oil and seeds are known to have <strong>in</strong>herent germicidal propertiesand have been <strong>in</strong> use for Ayurvedic (herbal) medic<strong>in</strong>es <strong>in</strong> India for a longtime. Burn<strong>in</strong>g neem leaves <strong>in</strong> the even<strong>in</strong>g is a common practice <strong>in</strong> rural Indiato repel mosquitoes. Neem is widely grown <strong>in</strong> other Asian countries andtropical and subtropical areas of Africa, America and Australia. It grows well<strong>in</strong> poor, shallow, degraded and sal<strong>in</strong>e soil. Neem can be considered as themost important among all bio<strong>pest</strong>icides for controll<strong>in</strong>g <strong>pest</strong>s. Neem <strong>pest</strong>icidesdo not leave any residue on the crop and therefore are preferred overchemical <strong>pest</strong>icides. In the past decade, neem has become a source of <strong>natural</strong><strong>pest</strong>icide due to its non-toxicity, environmental safety and so on, therebyreplac<strong>in</strong>g synthetic <strong>pest</strong>icides. Neem derivatives have been applied aga<strong>in</strong>stseveral species of storage <strong>pest</strong>s and crop <strong>pest</strong>s as leaves, oil, cake, extractsand as formulations <strong>in</strong> neem oil (Gahukar, 2000; Dhaliwal et al., 2004). Neem<strong>pest</strong>icides are thus a potential alternative to chemical-based <strong>pest</strong>icides andtheir use can avoid the dump<strong>in</strong>g of thousands of tonnes of agrochemicals onEarth every year.Neem-based <strong>pest</strong>icides are sold under trade names such as Margosan-O,Azat<strong>in</strong> Rose Defense, Shield-All, Triact and Bio-neem. They have been shownto control gypsy moths, leaf m<strong>in</strong>ers, sweet potato whiteflies, western flowerthrips, loopers, caterpillars and mealybugs as well as some of the <strong>plant</strong>diseases, <strong>in</strong>clud<strong>in</strong>g certa<strong>in</strong> mildews and rusts.

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