ISQ User Guide - Write Frame of Mind
ISQ User Guide - Write Frame of Mind
ISQ User Guide - Write Frame of Mind
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8 Troubleshooting<br />
How to Know When Your System Needs Maintenance<br />
How to Know When Your System Needs Maintenance<br />
Typically, you will notice that your instrument needs maintenance when you are analyzing<br />
your data on the computer. Some <strong>of</strong> the most common reasons and indications are as follows:<br />
• Contamination—If you notice excessive background in your mass spectra, it is usually an<br />
indication that your instrument is contaminated. Use the mass spectrum in the table<br />
below to understand the origin <strong>of</strong> the contamination. If you notice cleaning solvent<br />
peaks, it is usually an indication that your ion source cartridge was installed before it was<br />
completely dried.<br />
• Fingerprints—If you notice a series <strong>of</strong> mass peaks in your data that are 14 amu apart, it is<br />
usually an indication <strong>of</strong> fingerprint or other hydrocarbon contamination. To avoid<br />
fingerprints, you should wear clean, lint-free gloves when performing any type <strong>of</strong><br />
maintenance on a component in the vacuum manifold <strong>of</strong> the <strong>ISQ</strong>.<br />
• Air Leaks—If you notice a higher than normal vacuum pressure or poor sensitivity, it is<br />
usually an indication <strong>of</strong> an air leak. Check the last o-ring or ferrule you installed.<br />
Table 1. Common Contaminants<br />
Ions (m/z) To Monitor Compound Possible Source<br />
13,14,15,16 Methane CI gas<br />
18, 28, 32, 44 or 14, 16 H2O, N2 , O2 , CO2 or N, O Residual air and water, air leaks,<br />
outgassing from Vespel ferrules<br />
31, 51, 69, 100, 119, 131, 169, 181,<br />
214, 219, 264, 376, 414, 426, 464,<br />
502, 576, 614<br />
PFTBA and related ions PFTBA (tuning compound)<br />
31 Methanol Cleaning solvent<br />
43, 58 Acetone Cleaning solvent<br />
78 Benzene Cleaning solvent<br />
91, 92 Toluene or xylene Cleaning solvent<br />
105, 106 Xylene Cleaning solvent<br />
151, 153 Trichloroethane Cleaning solvent<br />
149 Plasticizer (phthalates) Use <strong>of</strong> vinyl or plastic gloves<br />
Peaks spaced 14 amu apart Hydrocarbons Fingerprints, foreline pump oil or other<br />
hydrocarbons<br />
90 <strong>ISQ</strong> <strong>User</strong> <strong>Guide</strong> Thermo Scientific