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POSTER PRESENTATIONS<br />
P 278<br />
Poster: Dressings<br />
TOPICAL WOUND HEALING MATERIALS BASED ON BIODEGRADABLE<br />
POLYSACCHARIDES WITH COMBINED ANTIBACTERIAL, ANTI-INFLAMMATORY<br />
AND TISSUE-FORMING ACTIVITY<br />
Olga Veselkina 1 , Andrew Savitsky 1 , Nikolay Petrishchev 2<br />
1 Closed Joint-Stock Company “VERTEX” (Saint Petersburg, Russia);<br />
2 The Saint Petersburg State Medical University named after I.P. Pavlov (Saint<br />
Petersburg, Russia).<br />
Aim: Evaluation of skin and mucosal wound healing efficiency of topically applied<br />
bioadhesive and biodegradable films with combined antibacterial, anti-inflammatory and<br />
tissue-forming activity.<br />
Methods: The films consisted of polysaccharides as carrier with different drug<br />
compositions. The study was performed utilizing rodent models of skin and mucosal<br />
wounds: a) The chemical burn of gingiva and periodontium induced by sulfuric acid.<br />
Four film compositions were studied (n=10, each).<br />
b) Linear excisional skin wound on the back of the animals. The strength of the cicatrice<br />
was determined by tensometry. Four film compositions were studied (n=10, each).<br />
c) Laser skin burn on the back of the animals. The films were applied to male and<br />
female rats (n=5, each).<br />
Results: The efficiency of films was evaluated by visual control, measuring the levels of<br />
inflammatory markers in the samples of peripheral blood or saliva and histological<br />
examination. Microbial contamination of the wounds was determined.<br />
In all cases the films exhibited distinct antibacterial and fungistatic effect. Application of<br />
the films reduces inflammation, accelerates wound reparation and leads to the twofold<br />
increase in cicatrice strength.<br />
Conclusions: Accelerated healing of laser burns was found in female rats compared to<br />
male ones. The time of complete epithelization shortened by 13% (p≤0.05). This could<br />
be attributed to sex differences in skin composition and susceptibility to laser irradiation.<br />
Smaller area of the primary eschar and edema in female rats was confirmed in the<br />
independent experiment of skin exposure to laser irradiation.<br />
POSTER: DRESSINGS<br />
P 279<br />
Poster: Dressings<br />
Effectiveness of advanced versus conventional wound dressings<br />
on healing of chronic wounds – a meta-analysis<br />
Stephan Jeff Rustenbach 1 , Katharina Herberger 1 , Kerstin Protz 1 , Matthias Augustin 2<br />
1 German Center for Health Services Research in Dermatology (CVderm) (Hamburg,<br />
Germany);<br />
2 Institute for Health Services Research in Dermatology and Nursing, University Clinics of<br />
Hamburg<br />
The treatment of chronic wounds is of high clinical and socio-economic importance.<br />
Wound dressings are essential in the treatment of chronic wounds and should be<br />
selected on valid and recent evidence. This meta-analysis will assess the effectiveness<br />
of advanced compared to conventional wound dressings in the healing of chronic<br />
wounds.<br />
In the meta-analysis published studies on chronic wounds with advanced wound<br />
dressing, were included, independent of the wound type and study design. The<br />
publications were evaluated in different professional associations in a multi-stage<br />
process. The analysis was based on meta-analytic methods.<br />
The mean odds ratio of complete healing was 1.52 favouring advanced over<br />
conventional dressings in 65 controlled trials. In 287 study conditions (n=170 controlled<br />
and uncontrolled studies), mean odds for advanced dressings were 0.47 in uncontrolled<br />
and 0.97 in controlled studies. The mean odds were 0.77 with conventional dressings in<br />
controlled studies. The overall healing rate was 33%. When causal treatment was<br />
applied, a reduced effect was observed.<br />
In contrast to published meta-analyses on the effectiveness of advanced dressings in the<br />
treatment of chronic wounds, this comprehensive meta-analysis includes all diagnoses<br />
of chronic wounds, all types of advanced wound dressings, and all types of empirical<br />
studies in this area of clinical research and care. A general superiority of advanced<br />
dressings on complete healing was shown. The generalizability of the results is limited<br />
by the methodological and report quality within studies identified, unexplained<br />
heterogeneity in study effects and possibly by publication bias.<br />
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