Here - EWMA 2013

E-POSTER PRESENTATIONS
EP 436
E-Poster: Acute Wounds
The Accelerated Epithelialization of Recombinant Epidermal
Growth Factor on Partial-thickness Skin Wounds
Junho Lee 1 , Jeong Tae Kim 2 , Yong-Ha Kim 1 , Tae-Gon Kim 1
1 Yeungnam University Hospital (Daegu, Korea);
2 Department of Plastic and Reconstructive Surgery, Hanyang University Medical Center
(Daegu, Korea)
Aim: Recent studies have already demonstrated experimentally that the topical
application of epidermal growth factor (EGF) accelerates the healing of partial-thickness
wounds. Although previous studies have proved the effect of recombinant human EGF
(rhEGF), the clinical use of rhEGF in case of patients have generated some controversy
in advantage. In this study, twelve patients had partial thickness wounds because of
burn and skin graft donor site were treated with rhEGF and we investigated the clinical
effect of rhEGF on partial thickness wounds of patients.
Methods: We evaluated two groups of patients had partial-thickness wounds. One
group (n=5) is consisted of the patients have second degree burn wounds, and the other
group (n=7) is consisted of the patients have donor site wounds after skin graft. Each
wound was divided two area, one area was applied twice daily with rhEGF and the other
area was treated without rhEGF. The extent of reepithelialized area was recorded by
percentage ratio. And the statistical analysis was conducted about the difference of the
number of days between two area until total wound was reepithelialized.
Results: In the group treated with rhEGF, the mean of time to healing was about 9.75
days, whereas, in the group without rhEGF, it was about 11.08 days. In the number of
days until total wound was reepithelialized, there were statistically significant difference
between two groups (P < 0.05)
Conclusion: It was concluded that the topical application of rhEGF accelerated the
healing of partial-thickness wound clinically.
E-POSTER: ACUTE WOUNDS
EP 437
E-Poster: Acute Wounds
APPLICATION OF BIOGEGRADABLE WOUND DRESSINGS IN TREATMENT OF
CHILDREN WITH DEEP BURNS.
Vera Soshkina 1 , Liudmila Budkevich 1 , Tatiana Astamirova 1
1 Moscow Scientific Institute of Paediatrics and Children Surgery (Moscow, Russia);
In the treatment of children with deep and partial-deep burn wounds is very important not
only to achieve restoration of the integrity of skin, but also a good cosmetic results.
Purpose: To determine the application of a synthetic skin substitute* for conservative
treatment of partial-deep burns, the use of this wound covering on measured grafts.
Materials and Methods: In the Moscow children’s burn cents from October 2012 in the
treatment of 6 children in the first three years of life (1.5 (0.9, 2.4)) with the local deep
and partial-deep burns from 1 to 4% TBSA (2 (1.5, 3)) was used a synthetic skin
substitute*. In 3 patients a conservative monotherapy of partial- deep local burns was
held, and the restoration of the integrity of the skin was noted in 13 (12, 15) days after
the injury. The formation of scars in post-burn areas was not occured. A synthetic skin
substitute used as a wound dressing in the postoperative period to grafts, measured 1:4
over 2 (1.5, 4)% TBSA in 3 patients. Graft engraftment with full restoration of integrity of
the skin marked by 9 (8, 10) the day after surgery.
Conclusions: The use of wound dressing* allows to avoid surgery in children with
partial deep wounds. Application of a synthetic skin substitute in postoperative period on
measured grafts reduces the healing of wounds with good cosmetic results in
catamnesis.
*Suprathel
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