Here - EWMA 2013

ORAL PRESENTATIONS
132
Free Paper Session: Diabetic Foot I
TREATMENT OF HARD-TO-HEAL DIABETIC FOOT ULCERS WITH A LEUCOCYTE
AND PLATELET-RICH FIBRIN PATCH – A PROSPECTIVE SCANDINAVIAN
MULTICENTER STUDY
Bo Jørgensen 1 , Magnus Löndahl 2 , Lise Tarnow 3 , Anna Marie Nielsen 4 ,
Morten Michelsen 5 , Anders Nilsson 6 , Mariusz Zakrzewski 7 , Tonny Karlsmark 1
1 Copenhagen Wound Healing Center (Copenhagen, Denmark);
2 Skåne University Hospital (Lund, Sweden);
3 Steno Diabetes Center A/S (Gentofte, Denmark);
4 Odense University Hospital (Odense, Denmark);
5 Herlev Hospital (Herlev, Denmark);
6 Ängelholm Hospital (Ängelholm, Sweden);
7 Kolding Hospital (Kolding, Denmark).
Aim: This prospective open multicentre study assessed the clinical performance of a
biologically active leucocyte and platelet rich fibrin patch 1 in non-healing diabetic foot
ulcers. The effect of treatment was assessed by area reduction and complete wound
closure within 12 and 20 weeks. The study was performed at multidisciplinary wound
care units in Denmark and Sweden.
Methods: A leucocyte and platelet rich fibrin patch was prepared from the patient’s own
blood, at the point of care. The patch was applied weekly for up to 19 weeks. The
primary outcomes were wounds healed within 12 and 20 weeks and time to healing.
Secondary outcome was change in wound area.
59 diabetic patients with chronic wounds (>6 weeks duration) were included for a twoweek
screening period. Wounds healing >40% during screening were not included. 41
patients were included and received treatment.
Results: Of 41 patients included for treatment 13 and 22 wounds healed within 12 and
20 weeks respectively. 5 patients were excluded during treatment, per protocol analysis
showed that 36% and 62% of patients healed within 12 and 20 weeks respectively.
Average wound duration at inclusion were 61 weeks. Mean time to complete healing
was 10.7. Study treatment enhanced ulcer area reduction (week -2-0 vs. 0-2, p