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E-POSTER: DRESSINGS<br />
E-Poster: Dressings<br />
EP 486<br />
EFFICACY TRIALS ON THE USE OF A NEW DRESSING FOR THE HEALING OF<br />
CUTS AND GRAZES: A RANDOMISED AND CONTROLLED TRIAL<br />
Tommaso Bianchi 1 , Elisabetta Ghelli 1 , Angela Peghetti 2<br />
1 AUSL Bologna, Bellaria Hospital, Dermatology Unit (Bologna, Italy);<br />
2 Bologna University Hospital (Bologna, Italy).<br />
Background: For many years health-related research has promoted significant<br />
developments in the field of wound care. Today, in fact, health care professionals have<br />
many types of products that exploit the principles proposed by research and enable the<br />
application of “Advanced” dressing systems. This has encouraged the delivery of clinical<br />
services and optimal management both in the context of dressing / treatment of wounds<br />
and in prevention aspects*.<br />
Objectives: The AISLeC scientific committee has prepared a randomised and controlled<br />
experiment at a specialist Clinical Centre in order to produce statistically significant<br />
results in relation to healing. The objectives of this study are: to evaluate and<br />
contextualise the use of one specific type of “advanced” wound dressing to demonstrate<br />
its clinical efficacy through the evaluation of healing rates (the study’s primary outcome),<br />
to support its use from a health economics perspective<br />
Materials and Methods: This study consists of a phase III randomised open trial<br />
between two parallel groups stratified by type of wound. The product to be analysed**<br />
belonging to the advanced dressing category, will be compared with normal dressing<br />
treatment according to the practice typically applied in the research centre. The<br />
traditional dressing consists of cotton gauze and a non-occlusive plaster.<br />
The research protocol was recorded in the Clinical Trial.gov database (registration<br />
number: NCT01573234), and authorisation of the ethics committee of reference was<br />
requested.<br />
Data analysis: With 180 evaluable wounds (90 per group) it will be possible to highlight<br />
the following: Assuming a difference in effectiveness of the dressings of approximately<br />
10%, with this number it can be stated that this difference in effectiveness is statistically<br />
significant with a power of 80%.<br />
The cases were considered equal to 5%, the probability of error alpha and the two tailed<br />
chi-squared test was used.<br />
Data analysis will be performed according to the intention to treat principles.<br />
Conclusions: Today, the research being carried out within the context of wound care<br />
provides few studies of high methodological quality. As a result, the treatment decisions<br />
tend to be determined on the basis of empirical evidence. Professionals therefore<br />
continue to be uncertain about the best treatment to be applied for cuts and grazes. This<br />
RCT aims to guide the choice of the best topical treatment on the basis of sound<br />
evidence.<br />
* Medical Device Regional Commission Advanced dressings for the treatment of acute and chronic wounds –<br />
From the evidence of the literature to daily practice February 2012 http://www.saluter.it/documentazione/rapporti/<br />
medicazioni_avanzate<br />
** MYSKIN cuts and grazes plaster, PIC Solution, ITALY<br />
EP 487<br />
E-Poster: Dressings<br />
AN IN VITRO INVESTIGATION OF STRUCTURE OF 4 ABSORBENT DRESSINGS<br />
USING SCANNING ELECTRON MICROSCOPY<br />
Valerie Edwards-Jones 1 , Vladimir Vishnyakov 1 , Pam Spruce 2<br />
1 Manchester Metropolitan University (Manchester, United Kingdom);<br />
2 TVRE Consulting (Stoke-On-Trent, United Kingdom).<br />
Absorbent dressings are used in the management of wounds and their primary function<br />
is to absorb excess exudate. However, an additional benefit may be to have the capacity<br />
to retain microorganisms.<br />
Aim: To observe the structure of dressings using scanning electron microscopy.<br />
Method: The structure of 4 dressings were investigated in wet and dry conditions and in<br />
the presence of four different microorganisms, Escherichia coli, Pseudomonas<br />
aeruginosa, methicillin resistant Staphylococcus aureus and Candida albicans using a<br />
Leica High Resolution Scanning Electron Microscope.<br />
Results: Dressing 1 A circular cart wheel structure was observed within the dressing,<br />
holding a mass of fibres in both dry and hydrated conditions. It was difficult to see any<br />
microorganisms within the dressing.<br />
Dressing 2 consisted of two types of fibres, smooth and striated in both dry and hydrated<br />
conditions. All microorganisms were easily found, attached to the fibres of the dressing.<br />
Dressing 3 consisted of a mass of smooth fibres that once hydrated disappeared into a<br />
gel-like matrix. Microorganisms could be seen embedded in the gel-like matrix.<br />
Dressing 4 consisted of a mass of fibres with irregularities on their surface. On hydration,<br />
a substance was observed adhered to the surface of the fibres. Microorganisms were<br />
attached to the fibres, often within the irregularities.<br />
Conclusions: Electron microscopy allowed the structure of the dressing to be observed<br />
in wet and dry conditions. Microorganisms were observed in dressings 2,3 and 4.<br />
Dressings: 1: Advadraw (Advencis), 2: Drawtex (Beier), 3: Aquacel Extra (Convatec): 4:Urgoclean (UrgoMedical)<br />
<strong>EWMA</strong> <strong>2013</strong><br />
COPENHAGEN<br />
15-17 May · <strong>2013</strong><br />
Danish Wound<br />
Healing Society<br />
279
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