Here - EWMA 2013

POSTER PRESENTATIONS
P 313
META-ANALYSIS: USE OF A SILVER-RELEASING FOAM DRESSING* IN
TREATMENT OF VENOUS LEG ULCERS
Poster: Leg Ulcer
Birte Petersen Jakobsen 1 , David Leaper 2 , Christian Münter 3 , Sylvie Meaume 4 ,
Alessandro Scalise 5 , Nacho Blanes Mompó 6 , Finn Gottrup 7
1 Coloplast A/S (Humlebæk, Denmark);
2 Cardiff University (Cardiff, United Kingdom);
3 Bramfelder Chaussee (Hamburg, Germany);
4 Hôpital Rothschild (Paris, France);
5 Ancona Politechnical University (Ancona, Italy);
6 Hospital de Manises (Manises, Spain);
7 Bispebjerg University Hospital (Copenhagen, Denmark).
Background: Venous leg ulcers are common and their failure to heal is often related to
a heavy bio-burden. Ionized silver has both anti-inflammatory and antimicrobial
properties. The ulcer healing properties of a silver-releasing foam dressing* has been
examined in 4 randomized controlled trials (RCTs).
Aim: To evaluate ulcer healing through a meta-analytic approach (statistical pooling)
after treatment with either a silver-releasing foam* dressing or a non-active dressing.
Patients and Methods: 685 subjects with pure or mixed venous leg ulcers were
included in the meta-analysis. The following outcomes were determined:
• Relative reduction of ulcer area over 4 weeks
• Responder rate; defined as the proportion of subjects with a relative ulcer area
reduction of ≥ 40% at 4 weeks
• Complete healing; defined as the proportion of subjects with a healed ulcer at 4
weeks.
Results: The treatment effects the 4 RCTs are illustrated in a Forest plot (Figure 1**).
Overall the silver-releasing foam dressing* showed a significant treatment effect (relative
reduction) (p