Here - EWMA 2013

E-POSTER: DEVICES & INTERVENTION
E-Poster: Devices & Intervention
EP 450
Comparison of antimicrobial efficacy of silver-containing and
non-silver containing dressings against P. aeruginosa and S.
aureus in vitro
Katie Bourdillon 1 , Kyle Turton 1 , Mathew Westmoreland 1
1 Systagenix (Gatwick, United Kingdom).
Silver Impregnated Activated Charcoal Dressings (SIAC) have been shown to reduce
bioburden in chronic wounds. However some reports have raised concerns over the
efficacy of such products. Recently, alternative Antimicrobial Bacterial Binding dressings
(ABB) have emerged which do not contain a recognized antimicrobial. This study
compared the antimicrobial efficacy of SIAC* and AAB† against clinically significant
organisms S. aureus (SA) and P. aeruginosa (PA) in vitro.
The antimicrobial efficacies of the dressings were evaluated in triplicate using a log10
reduction assay which exposes a sample of dressing to a bacterial culture. Samples
were removed over 3 hours and total viable counts (TVC) determined. The ABB was
tested in both 8-ply and 1-ply forms to reflect varying application methods in vivo.
SIAC dressings were highly active against both bacterial strains tested, with a ≥5 log10
reduction in PA and ≥3.7 log10 reduction in SA TVC observed within 3 hours. In contrast,
the 8 ply AAB had only a minor effect on TVC, with log10 reductions of ≤1.6 log10 units
observed for both bacterial strains. No significant reduction of TVC was seen for 1 ply
ABB compared to controls.
The SIAC dressings showed high antimicrobial efficacy, particularly against PA where
TVC were reduced significantly within 3 hours. In contrast the AAB dressing had only a
minor impact on the TVC of either bacteria tested. These results should be considered
when determining the appropriate dressing to use in the clinical setting.
*Actisorb Plus 25 and Actisorb 220 (Systagenix)
†Cutimed Sorbact (BSN Medical)
EP 451
E-Poster: Devices & Intervention
An in vitro and clinical assessment of a non-adherent,
antimicrobial wound dressing against a board spectrum of
bacteria
Alexander Waite 1 , Rachael McInnes 1 , Sharon Lindsay 1 , Rachel Simmons 1
1 Systagenix (Gatwick, United Kingdom).
Aim: To evaluate the antimicrobial efficacy of a non-adherent silver hydro-alginate
wound dressing, against a broad spectrum of bacteria. This was conducted using a
range of clinically relevant and predominant microbes found in wounds including
antibiotic resistant strains.
Methods: Analysis of the antimicrobial activity of the dressing was conducted in vitro
using a log10 reduction test procedure. In addition in vitro assessment of silver release
was conducted to give an indication of longevity of the antimicrobial activity. This data is
coupled with case reports detailing the treatment of infected chronic wounds, with focus
on both efficacy and ease of use.
Results: The in vitro analysis of the non-adherent silver dressing indicates antimicrobial
activity against the full range of clinically relevant microbes tested. This includes ≥4
log10 reduction within 3 hours and swab analysis that indicate bactericidal activity
against the antibiotic resistant strains tested. Assessment of silver release indicates a
sustained release over a period of 7 days, which would suggest antimicrobial efficacy is
also maintained over this timeframe. In addition, case studies indicate clinical efficacy
against infected wounds. Case reports also indicate ease of use due to the non-adherent
layer including reduced fibre shed and reduced discomfort on removal.
Conclusions: This non adherent silver hydro-alginate wound dressing has been shown
to have a sustained broad spectrum antimicrobial activity against clinically relevant
microbial strains including resistant strains. In addition the dressing was found to be
easy to remove and reduces wound disruption upon removal.
EWMA 2013
COPENHAGEN
15-17 May · 2013
Danish Wound
Healing Society
261