Here - EWMA 2013

E-POSTER PRESENTATIONS
EP 508
Effect of Collagen/ORC/Silver on Bacterial Proteases
E-Poster: Infection
Rachel Simmons 1 , Lorna McInroy 1 , Molly Gibson 1 , Claire Bartle 1 , Tanya Swaine 1 ,
Breda Cullen 1
1 Systagenix (Gatwick, United Kingdom).
Aim: To determine if a Collagen/ORC/Silver therapy can aid in bacterial load reduction
and bacterial protease activity reduction in chronic wounds.
Method: Collagen/ORC/Silver was tested against 11 bacterial strains, including
Methicillin-resistant Staphylococcus aureus, Methicillin-Resistant Staphylococcus
epidermidis and vancomycin-resistant Enterococci, on Log10 reduction to determine the
antimicrobial properties of this dressing. Collagen/ORC/Silver was tested against a
range of bacterial proteases as well as Staphylococcus aureus and Pseudomonas
aeruginosa supernatants to determine ability to reduce their proteolytic activity. Bacterial
proteases were measured in the wound fluid collected from a patient throughout
treatment to confirm Collagen/ORC/Silver therapy affects bacterial protease activity in a
wound environment.
Results: Collagen/ORC/Silver showed efficacy on the Log10 reduction against all
strains of bacteria tested, with reduction to minimum detectable limits after 24 hours.
Collagen/ORC/Silver reduced the protease activity of supernatants from S. aureus and
P. aeruginosa cultures to less than 5% of their original value after 24 hours, and
significantly reduced commercially available bacterial protease activity. This was
clinically verified in a recent case study, where the use of Collagen/ORC/Silver dressings
reduced the bacterial protease activity, measured in wound exudate after application.
Conclusion: Collagen/ORC/Silver is effective at reducing the activities of bacterial
proteases in vitro and in vivo as well as the bacterial load of common wound pathogens.
This study provides further evidence that Collagen/ORC/Silver can help to promote
wound healing while protecting the wound from infection.
E-POSTER: INFECTION
EP 509
E-Poster: Infection
EVIDENCE BASADED IN PRACTICE CLINICAL, USED OR NOT USED THE SILVER,
WHAT IS THE QUESTION?
Miriam Berenguer Pérez 1 , Estefania Farret Roig 1 , Tere Herrero Serrano 1 ,
M. Serra Comas i Antich 1 , Ana Garcia Bonillo 1 , Sol Taramon Garcia 1
1 ICS (Barcelona, Spain).
Aim: To demonstrate the effectiveness with cadexomer iodine with venous leg ulcers of
degree III and signs of infection without used dressings silver.Their utility in daily practice
in patients with diferents etiologies.
Methods: Descriptive study used 15 patients with venous leg ulcers.Previous decided
don’t used silver dressings, we revious guidelines SIGN (Scottish Intercollegiate
Guidelines Network), NICE (National Institute for health and clinical Excellence), la
Cocrhane Library use Mesh “ Chronic wounds AND Dressing* AND Silver dressing AND
healding. Finally decided used SIGN to reflect the most recent evidence on chronic
venous leg ulceration.
Results: After application for 2 weeks with cadexomer iodine, we observed a good
evolution of skin periulceral, a reduction of exudate,the reducing the size of the ulcer, an
atraumatic treatment and the supply of an adequate humidity to the wound frequently to
absorb according to the necessities of the wound simultaneously.A Silver dressings are
not recommended in the routine treatment of patients with venous leg ulcers (Grade of
recommedation A).
Conclusion: After these first experience with and the use of these dressings we saw a
reduction of the dressing change, an excellent exudate control with a lower risk of
macerations.The wound dressings were well tolerated and the easy applicability and
painless removability are much valued by both treating persons and patients.Evidence of
variation in both healing rates and recurrence rates of venous leg ulcers highlights the
need for an updated evidence based guideline to support practice.
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