PCT/2000/42 : PCT Gazette, Weekly Issue No. 42, 2000 - WIPO

42/2000
15244 PCT Gazette - Section I - Gazette du PCT 19 Oct/oct 2000
(30) 60/128,593 9 Apr/avr 1999
(09.04.1999)
US
(43) 19 Oct/oct 2000 (19.10.2000)
(54) METHODS AND COMPOSITIONS
FOR DEGRADATION AND/OR INHI-
BITION OF HER–FAMILY TYROSINE
KINASES
PROCEDES ET COMPOSITIONS
PERMETTANT LA DEGRADATION
ET/OU L’INHIBITION DES TYRO-
SINE KINASES APPARTENANT A LA
FAMILLE HER
(71) SLOAN–KETTERING INSTITUTE
FOR CANCER RESEARCH [US/US];
1275 York Avenue, New York, NY 10021
(US).
(for all designated States except / pour tous
les États désignés sauf US)
(72, 75) ROSEN, Neal [US/US]; Office of Industrial
Affairs, Memorial Sloan Kettering
Cancer Center, 1275 York Avenue, New
York, NY 10021 (US). KUDUK, Scott, D.
[US/US]; Office of Industrial Affairs, Memorial
Sloan Kettering Cancer Center, 1275
York Avenue, New York, NY 10021 (US).
DANISHEFSKY, Samuel, J. [US/US]; Office
of Industrial Affairs, Memorial Sloan
Kettering Cancer Center, 1275 York Avenue,
New York, NY 10021 (US). ZHENG,
Furzhong, F. [CN/US]; Office of Industrial
Affairs, Memorial Sloan Kettering Cancer
Center, 1275 York Avenue, New York, NY
10021 (US). SEPP–LORENZINO, Laura
[US/US]; Office of Industrial Affairs, Memorial
Sloan Kettering Cancer Center, 1275
York Avenue, New York, NY 10021 (US).
OUERFELLI, Ouathek [TN/US]; Office
of Industrial Affairs, Memorial Sloan Kettering
Cancer Center, 1275 York Avenue, New
York, NY 10021 (US).
(74) PARSONS, Nancy, J. et al. / etc.; Oppedahl
& Larson LLP, P.O. Box 5068, Dillon, CO
80435–5068 (US).
(81) AE AG AL AM AT AU AZ BA BB BG BR
BY CA CH CN CR CU CZ DE DK DM DZ
EE ES FI GB GD GE GH GM HR HU ID
IL IN IS JP KE KG KP KR KZ LC LK LR
LS LT LU LV MA MD MG MK MN MW
MX NO NZ PL PT RO RU SD SE SG SI
SK SL TJ TM TR TT TZ UA UG US UZ
VN YU ZA ZW; AP (GH GM KE LS MW
SD SL SZ TZ UG ZW); EA (AM AZ BY
KG KZ MD RU TJ TM); EP (AT BE CH
CY DE DK ES FI FR GB GR IE IT LU MC
NL PT SE); OA (BF BJ CF CG CI CM GA
GN GW ML MR NE SN TD TG).
(51) 7 C07D 413/12, A61K 31/505, A61P 9/12,
C07D 413/14, 313/14, 239/56, 405/04
(11) WO 00/61579
(21) PCT/EP00/02976
(13) A1
(22) 4 Apr/avr 2000 (04.04.2000)
(25) de (26) de
(30) 199 16 719.2 13 Apr/avr 1999
(13.04.1999)
DE
(43) 19 Oct/oct 2000 (19.10.2000)
(54) NEW ENDOTHELIN CONVERTING
ENZYME INHIBITORS, THEIR PRO-
DUCTION AND THEIR USE
NOUVEAUX INHIBITEURS DE
L’ENZYME DE CONVERSION DE
L’ENDOTHELINE (ECE), LEUR PRO-
DUCTION ET LEUR UTILISATION
(71) BASF AKTIENGESELLSCHAFT
[DE/DE]; D–67056 Ludwigshafen (DE).
(for all designated States except / pour tous
les États désignés sauf US)
(72, 75) HILLEN, Heinz [DE/DE];
Max–Planck–Strasse 17, D–67454 Hassloch
(DE). KLING, Andreas [DE/DE]; Riegeler
Weg 14, D–68239 Mannheim (DE). LAU-
TERBACH, Arnulf [DE/DE]; Innsbrucker
Weg 7, D–67067 Ludwigshafen (DE).
ZECHEL, Johann–Christian [DE/DE];
Schreiberweg 7, D–69226 Nussloch (DE).
HERGENRÖDER, Stefan [DE/DE];
Hans–Böckler–Strasse 108, D–55128 Mainz
(DE). MARKERT, Claus, Otto [DE/DE];
Mannheimer Strasse 54, D–67105 Schifferstadt
(DE).
(74) BASF AKTIENGESELLSCHAFT;
D–67056 Ludwigshafen (DE).
(81) CN JP RO SI US; EP (AT BE CH CY DE
DK ES FI FR GB GR IE IT LU MC NL PT
SE).
(51) 7 C07D 413/12, A61K 31/44
(11) WO 00/61580 (13) A1
(21) PCT/GB00/01393
(22) 12 Apr/avr 2000 (12.04.2000)
(25) en (26) en
(30) 9908355.2 12 Apr/avr 1999
(12.04.1999)
(30) 60/141,470 29 Jun/juin 1999
(29.06.1999)
(43) 19 Oct/oct 2000 (19.10.2000)
GB
US
(54) SUBSTITUTED BICYCLIC HETEROA-
RYL COMPOUNDS AS INTEGRIN AN-
TAGONISTS
COMPOSES D’HETEROARYLE
BICYCLIQUE SUBSTITUE UTI-
LISES COMME ANTAGONISTES
DE L’INTEGRINE
(71) AVENTIS PHARMA LIMITED [GB/GB];
Aventis House, 50 Kings Hill Avenue, West
Malling, Kent ME19 4AH (GB).
(for all designated States except / pour tous
les États désignés sauf US)
(72, 75) CLARK, David, Edward [GB/GB];
Aventis Pharma Limited, Rainham Road
South, Dagenham, Essex RM10 7XS (GB).
EASTWOOD, Paul, Robert [GB/GB];
Aventis Pharma Limited, Rainham Road
South, Dagenham, Essex RM10 7XS (GB).
HARRIS, Neil, Victor [GB/GB]; Aventis
Pharma Limited, Rainham Road South,
Dagenham, Essex RM10 7XS (GB). Mc-
CARTHY, Clive [GB/GB]; Aventis Pharma
Limited, Rainham Road South, Dagenham,
Essex RM10 7XS (GB). MORLEY, Andrew,
David [GB/GB]; Aventis Pharma
Limited, Rainham Road South, Dagenham,
Essex RM10 7XS (GB). PICKETT, Stephen,
Dennis [GB/GB]; Aventis Pharma
Limited, Rainham Road South, Dagenham,
Essex RM10 7XS (GB).
(74) CAFFIN, Lee; Aventis Pharma Limited,
Rainham Road South, Dagenham, Essex
RM10 7XS (GB).
(81) AE AG AL AM AT AU AZ BA BB BG BR
BY CA CH CN CR CU CZ DE DK DM DZ
EE ES FI GB GD GE GH GM HR HU ID
IL IN IS JP KE KG KP KR KZ LC LK LR
LS LT LU LV MA MD MG MK MN MW
MX NO NZ PL PT RO RU SD SE SG SI
SK SL TJ TM TR TT TZ UA UG US UZ
VN YU ZA ZW; AP (GH GM KE LS MW
SD SL SZ TZ UG ZW); EA (AM AZ BY
KG KZ MD RU TJ TM); EP (AT BE CH
CY DE DK ES FI FR GB GR IE IT LU MC
NL PT SE); OA (BF BJ CF CG CI CM GA
GN GW ML MR NE SN TD TG).
(51) 7 C07D 417/12, 413/12, 471/04, A61K
31/427, 31/422, 31/437, A61P 3/10, 29/00,
37/02, 43/00, 19/10, 35/00
(11) WO 00/61581 (13) A1
(21) PCT/JP00/02216
(22) 6 Apr/avr 2000 (06.04.2000)
(25) ja (26) ja
(30) 11/99981 7 Apr/avr 1999
(07.04.1999)
(43) 19 Oct/oct 2000 (19.10.2000)
(54) AMINE DERIVATIVES
DERIVES AMINE
(71) SANKYO COMPANY, LIMITED
[JP/JP]; 5–1, Nihonbashi Honcho 3–chome,
Chuo–ku, Tokyo 103–8426 (JP).
(for all designated States except / pour tous
les États désignés sauf US)
(72, 75) FUJITA, Takashi [JP/JP]; Sankyo
Company, Limited, 2–58, Hiromachi
1–chome, Shinagawa–ku, Tokyo 140–8710
(JP). WADA, Kunio [JP/JP]; Sankyo Company,
Limited, 2–58, Hiromachi 1–chome,
Shinagawa–ku, Tokyo 140–8710 (JP).
OGUCHI, Minoru [JP/JP]; Sankyo Company,
Limited, 2–58, Hiromachi 1–chome,
Shinagawa–ku, Tokyo 140–8710 (JP).
HONMA, Hidehito [JP/JP]; Sankyo Company,
Limited, 2–58, Hiromachi 1–chome,
Shinagawa–ku, Tokyo 140–8710 (JP). FU-
JIWARA, Toshihiko [JP/JP]; Sankyo Company,
Limited, 2–58, Hiromachi 1–chome,
Shinagawa–ku, Tokyo 140–8710 (JP).
(74) OHNO, Akio et al. / etc.; Sankyo Company,
Limited, 2–58, Hiromachi 1–chome, Shinagawa–ku,
Tokyo 140–8710 (JP).
(81) AU BR CA CN CZ HU ID IL IN KR MX
NO NZ PL RU TR US ZA; EP (AT BE CH
CY DE DK ES FI FR GB GR IE IT LU MC
NL PT SE).
(51) 7 C07D 417/14, 413/14, 405/12, 471/04,
A61K 31/427, 31/422, 31/4184, 31/437,
A61P 3/10, 29/00, 37/02, 43/00, 3/06, 3/04,
9/12, 9/10, 15/00, 9/00
(11) WO 00/61582 (13) A1
(21) PCT/JP00/02217
(22) 6 Apr/avr 2000 (06.04.2000)
(25) ja (26) ja
JP