Toxicology of Industrial Compounds

Recommendations

Info

86 METHODS FOR THE DETERMINATION OF REACTIVE COMPOUNDS Figure 6.7 TLC chromatograms of DNA adducts in gills and livers of rainbow trouts, exposed for 3 months to waste water or control water. Top: control water, liver DNA (left chromatogram), gill DNA (right chromatogram); bottom: waste water, liver DNA (left chromatogram), gill DNA (right chromatogram). Conclusions Each method, although inherently chemically-specific, has its advantages and limitations depending on the adduct-type. The continued rapid development of the technologies described for assessing biomarkers should result in more accurate assessment of the intracellular reactions of chemicals and thereby provide information about the mechanism of toxicity of a compound under investigation.
Acknowledgements Grateful thanks to Drs Markus Joppich and Regula Joppich-Kuhn for haemoglobin adduct analyses and Dr Sandra Steiner for the development of the fluorescence assay for HMEdAp. References P.SAGELSDORFF 87 BAILEY, E., FARMER, P.B. and SHUKER, D.E.G., 1987, Estimation of exposure to alkylating carcinogens by the GC-MS determination of adducts to haemoglobin and nucleic acid bases in urine, Arch. Toxicol., 60, 187–91. BAILEY, E., BROOKS, A.G., BIRD, I., FARMER, P.B. and STREET, B., 1990, Monitoring exposure to 4,4′-methylenedianiline by the GC/MS determination of adducts to haemoglobin, Anal. Biochem., 190, 175–81. BAKTHAVACHALAM, J., ABEL-BAKY, S. and GIESE, R.W., 1991, Release of 2aminofluorene from N-(deoxyguanosine-8-yl)-2-aminofluorene by hydrazinolysis, J.Chromatogr., 538, 447–51. BEACH, A.C. and GUPTA, R.C., 1992, Human biomonitoring and the 32 Ppostlabelling assay, Carcinogenesis, 13, 1053–74. BROOKS, P., 1977, The role of covalent binding in carcinogenicity, in Jollow, D.J. et al. (Eds) Biological Reactive Intermediates, pp. 470–480, New York: Plenum. DAY, B.W., NAYLOR, S., GAN, L.-S., SHALI, Y., NGUYEN, T.T., SKIPPER, P. L., WISHNOK, J.S. and TANNENBAUM, S.R., 1990, Molecular dosimetry of polycyclic aromatic hydrocarbon epoxides and diol epoxides via haemoglobin adducts, Cancer Res., 50, 4611. ETAD Report, 1990, On the carcinogenic potential of diarylide azo pigments based on 3,3′-dichlorobenzidine, T 2028-CA, Toxicological Subcommittee of ETAD (TSC). FEDTKE, N., BOUCHERON, J.A., WALKER, V.E. and SWENBERG, J.A., 1990, Vinyl chloride induced DNA adducts: II: formation and persistence of 7-(2'oxoethyl) guanine and N 2 ,3-ethenoguanine in rat tissue DNA. Carcinogenesis, 11, 1278–1292. GREEN, L.C., SKIPPER, P.L., TURESKY, R.J., BRYANT, M.S. and TANNENBAUM, S.R., 1984, In vivo dosimetry of 4-aminobiphenyl in rats via a cysteine adduct in haemoglobin, Cancer Res., 44, 4254–9. GROOT, A.J.L., JANSEN, J.G., VAN WALKENBURG, C.F.M. and ZEELAND, A.A., 1994, Molecular dosimetry of 7-alkyl- and O 6 -alkylguanine in DNA by electrochemical detection, Mutat. Res., 307, 61–6. GUPTA, R.C., 1985, Enhanced sensitivity of 32 P-postlabelling analysis of aromatic carcinogen: DNA adducts, Cancer Res., 45, 5656–62. IARC, 1982, Monographs of the carcinogenic risk of chemicals to humans: some industrial chemicals and dyestuffs. 3,3′-Dichlorobenzidine and its hydrochloride, International Agency for the Research on Cancer, Vol. 29, pp. 239–56. JAIN, R. and SHARMA, M., 1993, Fluorescence postlabelling assay of DNA damage induced by N-methyl-nitrosourea, Cancer Res., 53, 2771–4.
Page 2 and 3:
Toxicology of Industrial Compounds
Page 4 and 5:
This edition published in the Taylo
Page 6 and 7:
8. Pulmonary Toxicity Studies with
Page 8 and 9:
Preface A large number of chemical
Page 10 and 11:
Contributors May Akrawi Department
Page 12 and 13:
Beverly M.Kulig TNO Toxicology, Dep
Page 14 and 15:
Richard A.Versen Schuller MTC, Heal
Page 16 and 17:
1 Biomonitoring and Absorption of I
Page 18 and 19:
4 BIOMONITORING AND ABSORPTION OF I
Page 20 and 21:
Page 22 and 23:
Page 24 and 25:
10 BIOMONITORING AND ABSORPTION OF
Page 26 and 27:
2 Toxicokinetics and Biodisposition
Page 28 and 29:
14 TOXICOKINETICS AND BIODISPOSITIO
Page 30 and 31:
Page 32 and 33:
Page 34 and 35:
Page 36 and 37:
Page 38 and 39:
Page 40 and 41:
Page 42 and 43:
Page 44 and 45:
Page 46 and 47:
Page 48 and 49:
Page 50 and 51: 3 Metabolic Activation of Industria
Page 52 and 53: 38 METABOLIC ACTIVATION OF INDUSTRI
Page 58 and 59: 4 Sizing up the Problem of Exposure
Page 60 and 61: 46 SIZING UP THE PROBLEM OF EXPOSUR
Page 74 and 75: 5 Metabolism of Reactive Chemicals
Page 76 and 77: 62 METABOLISM OF REACTIVE CHEMICALS
Page 86 and 87: 6 Methods for the Determination of
Page 88 and 89: 74 METHODS FOR THE DETERMINATION OF
Page 104 and 105: PART THREE Pulmonary toxicology of
Page 106 and 107: 92 CARCINOGENIC POTENTIAL OF MAN-MA
Page 114 and 115: 100 CARCINOGENIC POTENTIAL OF MAN-M
Page 132 and 133: 118 PULMONARY TOXICITY STUDIES WITH
Page 144 and 145: 130 PULMONARY HYPERREACTIVITY TO IN
Page 150 and 151:
136 PULMONARY HYPERREACTIVITY TO IN
Page 152 and 153:
10 Mechanisms of Pulmonary Sensitiz
Page 154 and 155:
140 MECHANISMS OF PULMONARY SENSITI
Page 156 and 157:
Page 158 and 159:
Page 160 and 161:
Page 162 and 163:
Page 164 and 165:
150 OCCUPATIONAL ASTHMA INDUCED BY
Page 166 and 167:
Page 168 and 169:
Page 170 and 171:
Page 172 and 173:
12 Biomarkers and Risk Assessment K
Page 174 and 175:
160 BIOMARKERS AND RISK ASSESSMENT
Page 176 and 177:
Page 178 and 179:
Page 180 and 181:
Page 182 and 183:
168 EXTRAPOLATION OF TOXICITY DATA
Page 184 and 185:
Page 186 and 187:
Page 188 and 189:
Page 190 and 191:
Page 192 and 193:
Page 194 and 195:
14 Molecular Approaches to Assess C
Page 196 and 197:
182 MOLECULAR APPROACHES TO ASSESS
Page 198 and 199:
Page 200 and 201:
Page 202 and 203:
Page 204 and 205:
Page 206 and 207:
Page 208 and 209:
Page 210 and 211:
Page 212 and 213:
198 EVALUATION OF TOXICITY TO THE I
Page 214 and 215:
Page 216 and 217:
Page 218 and 219:
Page 220 and 221:
Page 222 and 223:
208 USE OF LONG-TERM CULTURES OF HE
Page 224 and 225:
Page 226 and 227:
Page 228 and 229:
Page 230 and 231:
Page 232 and 233:
Page 234 and 235:
Page 236 and 237:
PART FIVE Mechanisms of toxicity of
Page 238 and 239:
224 PEROXISOME PROLIFERATION normal
Page 240 and 241:
226 PEROXISOME PROLIFERATION demons
Page 242 and 243:
228 PEROXISOME PROLIFERATION Specie
Page 244 and 245:
230 PEROXISOME PROLIFERATION intend
Page 246 and 247:
232 PEROXISOME PROLIFERATION BENTLE
Page 248 and 249:
234 PEROXISOME PROLIFERATION KRAUPP
Page 250 and 251:
236 PEROXISOME PROLIFERATION POPP,
Page 252 and 253:
18 Neurotoxicity Testing of Industr
Page 254 and 255:
240 NEUROTOXICITY TESTING OF INDUST
Page 256 and 257:
Page 258 and 259:
Page 260 and 261:
Page 262 and 263:
Page 264 and 265:
Page 266 and 267:
Page 268 and 269:
Page 270 and 271:
256 ENDOCRINE TOXICOLOGY OF THE THY
Page 272 and 273:
Page 274 and 275:
Page 276 and 277:
Page 278 and 279:
Page 280 and 281:
Page 282 and 283:
Page 284 and 285:
Page 286 and 287:
Page 288 and 289:
Page 290 and 291:
Page 292 and 293:
Page 294 and 295:
20 Testing and Evaluation for Repro
Page 296 and 297:
282 TESTING AND EVALUATION FOR REPR
Page 298 and 299:
Page 300 and 301:
Page 302 and 303:
Page 304 and 305:
Page 306 and 307:
Page 308 and 309:
Page 310 and 311:
Page 312 and 313:
Page 314 and 315:
PART SIX Toxicity of selected class
Page 316 and 317:
302 SPECIAL POINTS IN THE TOXICITY
Page 318 and 319:
Page 320 and 321:
Page 322 and 323:
Page 324 and 325:
310 TOXICOLOGY OF TEXTILE CHEMICALS
Page 326 and 327:
Page 328 and 329:
Page 330 and 331:
Page 332 and 333:
318 ANTIOXIDANTS AND LIGHT STABILIS
Page 334 and 335:
Page 336 and 337:
Page 338 and 339:
Page 340 and 341:
Page 342 and 343:
Page 344 and 345:
Page 346 and 347:
Page 348 and 349:
Page 350 and 351:
Page 352 and 353:
Page 354 and 355:
340 TOXICOLOGY OF SURFACTANTS Inter
Page 356 and 357:
342 TOXICOLOGY OF SURFACTANTS Figur
Page 358 and 359:
344 TOXICOLOGY OF SURFACTANTS probl
Page 360 and 361:
346 TOXICOLOGY OF SURFACTANTS nonio
Page 362 and 363:
348 TOXICOLOGY OF SURFACTANTS and t
Page 364 and 365:
350 TOXICOLOGY OF SURFACTANTS long-
Page 366 and 367:
352 TOXICOLOGY OF SURFACTANTS COULS
Page 368 and 369:
354
Page 370 and 371:
25 Low Dose of a Genotoxic Carcinog
Page 372 and 373:
358 CARCINOGENESIS AT LOW DOSE Tabl
Page 374 and 375:
360 CARCINOGENESIS AT LOW DOSE year
Page 376 and 377:
26 Controversial Mechanistic and Re
Page 378 and 379:
364 CONTROVERSIAL ISSUES IN SAFETY
Page 380 and 381:
Page 382 and 383:
Page 384 and 385:
Page 386 and 387:
Page 388 and 389:
374 INDEX 2-bromo-glutathionyl 64 B
Page 390 and 391:
376 INDEX Gas chromatography/mass s
Page 392 and 393:
378 INDEX mRNA analysis 211 Mutagen
Page 394 and 395:
380 INDEX Surfactants 338-55 acute
show all

Toxicology of Industrial Compounds

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?