Toxicology of Industrial Compounds

32 TOXICOKINETICS AND BIODISPOSITION OF INDUSTRIAL CHEMICALS
Figure 2.12 Physiologically based toxicokinetic model for description of butadiene
distribution and metabolism in mice, rats and humans. Gas exchange occurs in the
alveoli of the lung. Metabolism occurs in both the alveolar and bronchial areas of
the lung and in the liver. Metabolic activity in the three other compartments is
ignored (Evelo et al., 1993).
species. There are, however, large interspecies differences in the lung vs
liver activities: mice>rats>humans/monkeys.
The PBTK model used to describe butadiene distribution and metabolism
in mice, rats and humans is shown in Figure 2.12. Gas exchange is
supposed to occur in the alveoli of the lung and metabolism in both the
alveolar and bronchial areas of the lung and in the liver. By using the
experimentally determined or estimated species-selective parameters for