Toxicology of Industrial Compounds

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Therefore, it was the aim of this workshop to contribute to the
investigation of industrial chemicals by focussing on the individual
structure, its biological fate, its potential toxicity to mammals and the
molecular mechanisms possibly underlying such adverse effects by
highlighting the use and significance of experimental toxicology, with
special emphasis on mechanistic aspects, in the safety assessment of
industrial compounds as well as to current regulatory and legal
considerations. Topics had been selected to review generally approved facts
and mechanisms, and to particularly address and explore areas of
investigative and regulatory uncertainty, thereby intending to bring
together the broadly diverse expertise and interests of academic
researchers, corporate scientists, experts in safety assessment and
representatives from regulatory authorities.
The following contributions reflect a substantial selection of the 27
lectures and six short communications presented during the workshop.
May they succeed in setting a landmark for the due change from the current
era of black-box toxicology and largely undifferentiated regulatory
treatment of industrial chemicals to the desirable toxicology and safety
assessment by structure in the future.
We gratefully acknowledge the substantial financial support by CIBA-
GEIGY and the RCC Group as well as the financial contributions of
ADME Bioanalysis, BASF, Henkel, Hüls, Lonza, Schering and Union
Carbide.
Our gratitude is also extended to Mrs Ch.Zehnder for secretarial
assistance and to Taylor & Francis for continuous support, patience and
encouragement to make this publication possible.
H.Thomas
R.Hess
F.Waechter