Toxicology of Industrial Compounds

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328 ANTIOXIDANTS AND LIGHT STABILISERS: TOXIC EFFECT F, respectively. For Compound F, which appeared to be the most potent inducer of peroxisomal β-oxidation and lauric acid 12-hydroxylase activities, a concomitant strong 90 per cent reduction of morphine UDPglucuronosyltrasferase and marked 2.5-fold increase in bilirubin UDPglucuronosyltransferase activity was recorded (Table 23.7). Electron microscopy confirmed what had already been indicated by changes in the investigated enzyme levels, a striking proliferation of peroxisomes with the same appearance of these organelles regardless of the compound tested: vigorous increase in number, a striking number of markedly enlarged peroxisomes frequently containing matrical inclusions (matrical plates) and peroxisomes forming arrays or clusters (polyperoxisomes) in the virtual absence of any significant proliferation of smooth endoplasmic reticulum (data not shown). Consequently, the hepatotrophic effects of the tested benzotriazole-based light stabilisers were clearly assigned to their action as peroxisome proliferators in rat liver. Mindful of the different durations of treatment their potency was found to rank in the order Compound E
Table 23.7 The effect of various benzotriazole-based light stabilizers on selected biochemical parameters related to and indicative for a peroxisome proliferator type enzyme induction in male rat liver H.THOMAS ET AL. 329 Notes: dnt: dose level not tested. nd: not determined. Cyanide-insensitive peroxisomal fatty acid -oxidation and cytosolic glutathione S-transferase activities were determined with [l-14C]-palmitoyl-CoA and1-chloro2,4-dinitrobenzene as substrate, respectively. Values are means±standard deviation of 10 control and 5 treated animals (a, b) or 8 animals (c) or 5 animals per group (d). Asterisks indicate results significantly different (two-sided Dunnett’s test) from control: * p
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Toxicology of Industrial Compounds
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This edition published in the Taylo
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8. Pulmonary Toxicity Studies with
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Preface A large number of chemical
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Contributors May Akrawi Department
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Beverly M.Kulig TNO Toxicology, Dep
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Richard A.Versen Schuller MTC, Heal
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1 Biomonitoring and Absorption of I
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4 BIOMONITORING AND ABSORPTION OF I
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10 BIOMONITORING AND ABSORPTION OF
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2 Toxicokinetics and Biodisposition
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14 TOXICOKINETICS AND BIODISPOSITIO
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3 Metabolic Activation of Industria
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38 METABOLIC ACTIVATION OF INDUSTRI
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4 Sizing up the Problem of Exposure
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46 SIZING UP THE PROBLEM OF EXPOSUR
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5 Metabolism of Reactive Chemicals
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62 METABOLISM OF REACTIVE CHEMICALS
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6 Methods for the Determination of
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74 METHODS FOR THE DETERMINATION OF
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PART THREE Pulmonary toxicology of
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92 CARCINOGENIC POTENTIAL OF MAN-MA
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100 CARCINOGENIC POTENTIAL OF MAN-M
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118 PULMONARY TOXICITY STUDIES WITH
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130 PULMONARY HYPERREACTIVITY TO IN
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10 Mechanisms of Pulmonary Sensitiz
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140 MECHANISMS OF PULMONARY SENSITI
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150 OCCUPATIONAL ASTHMA INDUCED BY
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12 Biomarkers and Risk Assessment K
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160 BIOMARKERS AND RISK ASSESSMENT
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168 EXTRAPOLATION OF TOXICITY DATA
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14 Molecular Approaches to Assess C
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182 MOLECULAR APPROACHES TO ASSESS
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198 EVALUATION OF TOXICITY TO THE I
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208 USE OF LONG-TERM CULTURES OF HE
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PART FIVE Mechanisms of toxicity of
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224 PEROXISOME PROLIFERATION normal
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226 PEROXISOME PROLIFERATION demons
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228 PEROXISOME PROLIFERATION Specie
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230 PEROXISOME PROLIFERATION intend
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232 PEROXISOME PROLIFERATION BENTLE
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234 PEROXISOME PROLIFERATION KRAUPP
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236 PEROXISOME PROLIFERATION POPP,
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18 Neurotoxicity Testing of Industr
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240 NEUROTOXICITY TESTING OF INDUST
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256 ENDOCRINE TOXICOLOGY OF THE THY
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Page 292 and 293: 278 ENDOCRINE TOXICOLOGY OF THE THY
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Page 314 and 315: PART SIX Toxicity of selected class
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Page 370 and 371: 25 Low Dose of a Genotoxic Carcinog
Page 372 and 373: 358 CARCINOGENESIS AT LOW DOSE Tabl
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Page 376 and 377: 26 Controversial Mechanistic and Re
Page 378 and 379: 364 CONTROVERSIAL ISSUES IN SAFETY
Page 388 and 389: 374 INDEX 2-bromo-glutathionyl 64 B
Page 390 and 391: 376 INDEX Gas chromatography/mass s
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378 INDEX mRNA analysis 211 Mutagen
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380 INDEX Surfactants 338-55 acute
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