Toxicology of Industrial Compounds

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Contributors May Akrawi Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK Robert Anderson Schuller MTC, Health, Safety and Environmental Department, Toxicology Group, PO Box 625005, Littleton, CO 80162–5005, USA J.Paul Aston Sittingbourne Research Centre, Sittingbourne, Kent ME9 8AG, UK Christopher K.Atterwill CellTox Centre, University of Hertfordshire, Hatfield Campus, College Lane, Hatfield AL10 9AB, UK Samuel P.Aylward CellTox Centre, University of Hertfordshire, Hatfield Campus, College Lane, Hatfield AL10 9AB, UK Peter J.van Bladeren TNO Nutrition and Food Research, PO Box 360, Utrechtseweg 48, NL-3700 AJ Zeist, The Netherlands Hermann M.Bolt Institut für Arbeitsphysiologie, Universität Dortmund, Ardeystrasse 67, D-44139 Dortmund, Germany Charles J.Butterick Texas Technical Health Sciences Centre, Lubbock, TX, USA D.Bruce Campbell Servier Research and Development, Fulmer Hall, Windmill Road, Fulmer, Slough SL3 6HH, UK Gerald R.Chase Schuller MTC, Health, Safety and Environmental Department, Toxicology Group, PO Box 625005, Littleton, CO 80162–5005, USA
x Sandra Coecke Vrije Universiteit Brussel, Department of Toxicology, Laarbeeklaan 103 B-1090, Brussels, Belgium Jan N.M.Commandeur Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit van Amsterdam, De Boelelaan 1083, H1081 NL-V Amsterdam, The Netherlands Peter Dollenmeier CIBA-GEIGY Ltd., R-1002.2.62, PO Box CH-4002 Basel, Switzerland Jacqueline G.M.van Engelen Coronel Laboratory, University of Amsterdam, Academic Medical Centre, Meibergdreef 15, NL-1105 Amsterdam, The Netherlands Norbert Fedtke Hüls AG, Bau 2328/PB 12, D-45764 Marl, Germany Steven R.Frame DuPont Central Research and Development, Haskell Laboratory, PO Box 50, Elkton Road, Newark, DE 19714–0050, USA Heinz-Peter Gelbke BASF AG, Abt. Toxikologie, D-67056 Ludwigshafen, Germany Jan-Bert P.Gramsbergen Department of Public Health, Erasmus University, Rotterdam, The Netherlands Mark A.Hartsky DuPont Central Research and Development, Haskell Laboratory, PO Box 50, Elkton Road, Newark, DE 19714–0050, USA Kari Hemminki CNT, Karolinska Institute, Novum, S-141 57 Huddinge, Sweden Thomas W.Hesterberg Schuller MTC, Health, Safety and Environmental Department, Toxicology Group, PO Box 625005, Littleton, CO 80162–5005, USA Elisabeth M.G.Hoogendijk TNO Toxicology, Department of Neurotoxicology, PO Box 5815, NL-2280 HV Rijswijk, The Netherlands Sanja Keži Coronel Laboratory, University of Amsterdam, Academic Medical Centre, Meibergdreef 15, NL-1105 Amsterdam, The Netherlands Ian Kimber Zeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
Page 2 and 3: Toxicology of Industrial Compounds
Page 4 and 5: This edition published in the Taylo
Page 6 and 7: 8. Pulmonary Toxicity Studies with
Page 8 and 9: Preface A large number of chemical
Page 12 and 13: Beverly M.Kulig TNO Toxicology, Dep
Page 14 and 15: Richard A.Versen Schuller MTC, Heal
Page 16 and 17: 1 Biomonitoring and Absorption of I
Page 18 and 19: 4 BIOMONITORING AND ABSORPTION OF I
Page 24 and 25: 10 BIOMONITORING AND ABSORPTION OF
Page 26 and 27: 2 Toxicokinetics and Biodisposition
Page 28 and 29: 14 TOXICOKINETICS AND BIODISPOSITIO
Page 50 and 51: 3 Metabolic Activation of Industria
Page 52 and 53: 38 METABOLIC ACTIVATION OF INDUSTRI
Page 58 and 59: 4 Sizing up the Problem of Exposure
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46 SIZING UP THE PROBLEM OF EXPOSUR
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5 Metabolism of Reactive Chemicals
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62 METABOLISM OF REACTIVE CHEMICALS
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6 Methods for the Determination of
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74 METHODS FOR THE DETERMINATION OF
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PART THREE Pulmonary toxicology of
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92 CARCINOGENIC POTENTIAL OF MAN-MA
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100 CARCINOGENIC POTENTIAL OF MAN-M
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118 PULMONARY TOXICITY STUDIES WITH
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130 PULMONARY HYPERREACTIVITY TO IN
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10 Mechanisms of Pulmonary Sensitiz
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140 MECHANISMS OF PULMONARY SENSITI
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150 OCCUPATIONAL ASTHMA INDUCED BY
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12 Biomarkers and Risk Assessment K
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160 BIOMARKERS AND RISK ASSESSMENT
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168 EXTRAPOLATION OF TOXICITY DATA
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14 Molecular Approaches to Assess C
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182 MOLECULAR APPROACHES TO ASSESS
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198 EVALUATION OF TOXICITY TO THE I
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208 USE OF LONG-TERM CULTURES OF HE
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PART FIVE Mechanisms of toxicity of
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224 PEROXISOME PROLIFERATION normal
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226 PEROXISOME PROLIFERATION demons
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228 PEROXISOME PROLIFERATION Specie
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230 PEROXISOME PROLIFERATION intend
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232 PEROXISOME PROLIFERATION BENTLE
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234 PEROXISOME PROLIFERATION KRAUPP
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236 PEROXISOME PROLIFERATION POPP,
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18 Neurotoxicity Testing of Industr
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240 NEUROTOXICITY TESTING OF INDUST
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256 ENDOCRINE TOXICOLOGY OF THE THY
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20 Testing and Evaluation for Repro
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282 TESTING AND EVALUATION FOR REPR
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PART SIX Toxicity of selected class
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302 SPECIAL POINTS IN THE TOXICITY
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310 TOXICOLOGY OF TEXTILE CHEMICALS
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318 ANTIOXIDANTS AND LIGHT STABILIS
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340 TOXICOLOGY OF SURFACTANTS Inter
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342 TOXICOLOGY OF SURFACTANTS Figur
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344 TOXICOLOGY OF SURFACTANTS probl
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346 TOXICOLOGY OF SURFACTANTS nonio
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348 TOXICOLOGY OF SURFACTANTS and t
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350 TOXICOLOGY OF SURFACTANTS long-
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352 TOXICOLOGY OF SURFACTANTS COULS
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25 Low Dose of a Genotoxic Carcinog
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358 CARCINOGENESIS AT LOW DOSE Tabl
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360 CARCINOGENESIS AT LOW DOSE year
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26 Controversial Mechanistic and Re
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364 CONTROVERSIAL ISSUES IN SAFETY
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374 INDEX 2-bromo-glutathionyl 64 B
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376 INDEX Gas chromatography/mass s
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378 INDEX mRNA analysis 211 Mutagen
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380 INDEX Surfactants 338-55 acute
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Toxicology of Industrial Compounds

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