Toxicology of Industrial Compounds

compound is known to pass the liver and to be systemically distributed
throughout the foetal body. Thus the endothelial cell injuries observed in
the course of the Segment II study are regarded secondary to the effect of
peroxisome proliferation and to have arisen as a consequence of oxidative
damage which has been demonstrated to occur in various endothelial cell
systems, for example as a result of iron-mediated oxygen free radical attack
(Brieland et al., 1992; Barchowsky et al., 1994; Krautschick et al., 1995).
Therefore, the observed foetotoxicity of Compound F in rats is regarded as
occurring solely as a consequence of and secondary to peroxisome
proliferation, and there is no evidence to assume that this effect as a result
of exposure to benzotriazole based light stabilisers may occur in species
that are non-responsive to the action of peroxisome proliferators as stated
above, including humans.
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