Toxicology of Industrial Compounds

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372 CONTROVERSIAL ISSUES IN SAFETY ASSESSMENT References MOOLGAVKAR, S.H. and KNUDSON, A.G., 1981, Mutation and cancer: a model for human carcinogenesis, Journal of the National Cancer Institute, 66, 1037–52. MOOLGAVKAR, S.H., DEWANJI, A. and VENZON, D.J., 1988, A stochastic two-stage model for cancer risk assessment, I. The hazard function and the probability of tumour. Risk Analysis, 8, 383–92. SIELKEN, R.L.JR, 1989, Useful tools for evaluating and presenting more science in quantitative cancer risk assessments, Toxic Substances Journal, 9, 353–404.
Absorption of organic solvents 3–7 Acceptable daily intake (ADI) 43, 168 Acetylcholinesterase (AChE) 238 N-acetyl-S-(5-ethoxy-l,2,4-thiadiazol-3yl-methyl) -L-cysteine (ET-MA) 26 N-acetyl-β-glucosaminidase (NAG) 117 Acid anhydrides 152–7 Acrylamide 238 Acrylonitrile 23, 313 Adduct determination 81–7 limitations of methods for 84 Adduct formation of reactive compounds 74 Adipate esters 223 Airway hyperreactivity 128, 131 Airway inflammation, animal models 129 Alachlor 208 Alcohol ethoxylates, anaesthetic properties 349 Alkaline phosphatase (ALP) 117 Alkylating agents 76–9 Alkyldeoxyguanosine adducts 186 Allergic contact dermatitis 137 Allometric equation 44, 46 Allometric scaling 44–55 Allometry 44 Antioxidants 316–39 Aromatic amines 74, 77 Ascorbate 241 Assessment factors (AFs) 366–71, 370 Astrocytes 240 ATP 78, 79, 159 Axonal proteins 238 Azo colorants 301 carcinogenic 301–6 Index Benzene 39 Benzidene 301 Benzo(a)pyrene (BP) 159, 186 1,4-benzothiazines 64 Benzotriazole-based light stabilisers 322–29 blood kinetics 323–29 blood metabolites 323–29 effects on rat dam and foetal liver 329–4 in vitro hydrolysis 323 liver enzyme induction 327–31 safety assessment 331, 334–7 BGA, collaborative study 199 Bioactivation mechanisms 11, 35–41 Biocides 208 Bioinactivation mechanisms 11 Biological effect monitoring (BEM) 19 Biological effects, determination of 189– 6 Biological monitoring (BM) 19–1 definition 2 organic solvents 2–3 Biomarkers glutathione conjugation products as 20–2 of neurotoxicity 238–4 Biotransformation 12 Bisphenol A diglycidylether (BPADGE) 83 Body metabolic potential 48 Body surface area (BSA) 46–8 BP-DNA adducts 187 Bromobenzene 63 Bromo-diglutathionyl hydroquinones 64
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Toxicology of Industrial Compounds
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This edition published in the Taylo
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8. Pulmonary Toxicity Studies with
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Preface A large number of chemical
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Contributors May Akrawi Department
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Beverly M.Kulig TNO Toxicology, Dep
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Richard A.Versen Schuller MTC, Heal
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1 Biomonitoring and Absorption of I
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4 BIOMONITORING AND ABSORPTION OF I
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10 BIOMONITORING AND ABSORPTION OF
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2 Toxicokinetics and Biodisposition
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14 TOXICOKINETICS AND BIODISPOSITIO
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3 Metabolic Activation of Industria
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38 METABOLIC ACTIVATION OF INDUSTRI
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4 Sizing up the Problem of Exposure
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46 SIZING UP THE PROBLEM OF EXPOSUR
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5 Metabolism of Reactive Chemicals
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62 METABOLISM OF REACTIVE CHEMICALS
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6 Methods for the Determination of
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74 METHODS FOR THE DETERMINATION OF
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PART THREE Pulmonary toxicology of
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92 CARCINOGENIC POTENTIAL OF MAN-MA
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100 CARCINOGENIC POTENTIAL OF MAN-M
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118 PULMONARY TOXICITY STUDIES WITH
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130 PULMONARY HYPERREACTIVITY TO IN
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10 Mechanisms of Pulmonary Sensitiz
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140 MECHANISMS OF PULMONARY SENSITI
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150 OCCUPATIONAL ASTHMA INDUCED BY
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12 Biomarkers and Risk Assessment K
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160 BIOMARKERS AND RISK ASSESSMENT
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168 EXTRAPOLATION OF TOXICITY DATA
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14 Molecular Approaches to Assess C
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182 MOLECULAR APPROACHES TO ASSESS
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198 EVALUATION OF TOXICITY TO THE I
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208 USE OF LONG-TERM CULTURES OF HE
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PART FIVE Mechanisms of toxicity of
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224 PEROXISOME PROLIFERATION normal
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226 PEROXISOME PROLIFERATION demons
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228 PEROXISOME PROLIFERATION Specie
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230 PEROXISOME PROLIFERATION intend
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232 PEROXISOME PROLIFERATION BENTLE
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234 PEROXISOME PROLIFERATION KRAUPP
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236 PEROXISOME PROLIFERATION POPP,
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18 Neurotoxicity Testing of Industr
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240 NEUROTOXICITY TESTING OF INDUST
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256 ENDOCRINE TOXICOLOGY OF THE THY
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20 Testing and Evaluation for Repro
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282 TESTING AND EVALUATION FOR REPR
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PART SIX Toxicity of selected class
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302 SPECIAL POINTS IN THE TOXICITY
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310 TOXICOLOGY OF TEXTILE CHEMICALS
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318 ANTIOXIDANTS AND LIGHT STABILIS
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320 ANTIOXIDANTS AND LIGHT STABILIS
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Page 372 and 373: 358 CARCINOGENESIS AT LOW DOSE Tabl
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Page 376 and 377: 26 Controversial Mechanistic and Re
Page 378 and 379: 364 CONTROVERSIAL ISSUES IN SAFETY
Page 388 and 389: 374 INDEX 2-bromo-glutathionyl 64 B
Page 390 and 391: 376 INDEX Gas chromatography/mass s
Page 392 and 393: 378 INDEX mRNA analysis 211 Mutagen
Page 394 and 395: 380 INDEX Surfactants 338-55 acute
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