Toxicology of Industrial Compounds

asbestos (10 mg m −3 ) were included in the study. The crocidolite exposure
had to be stopped at 10 months due to excessive mortality resulting from
lung toxicity. The results are summarized in Table 7.5. Crocidolite
exposure resulted in lung fibrosis, a significant increase in lung tumors, and
a single mesothelioma. Rock wool, but not slag wool, exposure at 16 and
30 mg m −3 resulted in minimal lung fibrosis. However, neither rock wool
nor slag wool exposure resulted in mesotheliomas or a significant increase
in lung tumors.
Lung burden analyses
T.W.HESTERBERG ET AL. 101
Table 7.3 Combined summary of lung pathology findings: chrysotile and RCF1
from RCF MTD study in rats; and RCF multidose study in rats
a WHO fibers=fibers with length/diameter ≥3, length >5 µm, and diameter