Toxicology of Industrial Compounds

374 INDEX
2-bromo-glutathionyl 64
Bromohydroquinone 63–5
o-bromophenol 63
Bronchial challenge tests 149
Bronchial hyperreactivity 151
Bronchoalveolar lavage 117, 123
1,3-butadiene
PBPK/PBTK model 16
physiologically based toxicokinetic
modeling 31–3
2-butoxyacetic acid (BAA) 172–80
2-butoxyethanol, PBPK/PBTK model
166–4, 172–80
Calcium 245–9, 250, 267
Cancer risk
‘absolute’ 191
assessment 188–6
definitions 356
management of 181
Carbamazepine 322
Carbendazim 285–8
Carbon disulphide 238
Carcinogen(esis) 179–6, 356
azo colorants 301–6
DNA-reactive 356
dose-response relationship in 356
epidemiological approaches to
detect and identify 183–9
genotoxic 181–8
identification of 183–93
peroxisome proliferation 224–30
role of CYPs in activation and
detoxication of 206
spontaneous process 356, 357–3
surfactants 350
Carcinogenic potency 181
Carcinogenic Substances Regulation
301
Catabolic metabolism 260
Catalase 241
Cell-mediated immune responses in
chemical respiratory allergy 142–6
Cellular nucleophiles 73
Cerebral calcium accumulation 240
Chemical pesticides, immunotoxicity of
203
Chemical respiratory allergy, cellmediated
immune responses in 142–6
Chlordecone 241
Chlorinated solvents 223
Chloroform 38–1
Chromates 301
Chrysotile asbestos fibres
pulmonary toxic effects 116–30
size-separation methods 118–3
Classification systems 368–3
Color Index 301
Colorants (dyes and pigments) 301–10
regulatory aspects (FRG) 304–7
Cosmetics 208
Cultured porcine thyrocytes 261
Cyclophosphamide 286–90
Cytochrome P-450 (CYP) 15, 60, 74,
206–15, 318, 327, 332
Cytokine products of murine Th 1 and
Th 2 cells 141
Cytokines 140
Dangerous compounds 208
1,2-DCV-Cys 29, 31
DCV-G 29
1,2-DCV-G 29, 31
1,2-DCV-Nac 29
2,2-DCV-Nac 29
Dermal uptake of organic solvents 5–7
Detoxication, enzymes involved in 60–4
Developmental neurotoxins 247–2
Diagonal radioactive zones (DRZ) 158
Diarylide pigments 81–3
1,2-dibromoethane 40, 65–8
3,3′-dichlorobenzidine (DCB) 81–3,
301, 303
1,2-dichloroethane 65–8
2,5-dichloro-3-(glutathion-S-y1)
hydroquinone 64
Dichloromethane 39
1,3-dichloropropene (DCP) 21–3
S-(l,2-dichlorovinyl)glutathione. See 1,
2-DCV-G
di-(2-ethylhexyl)adipate (DEHA) 223,
224, 227, 229–4
di-(2-ethylhexyl)phthalate (DEHP) 223,
224, 227–4, 286, 287