Toxicology of Industrial Compounds

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8. Pulmonary Toxicity Studies with Man-Made Organic Fibres: Preparation and Comparisons of Size-separated Para-aramid with Chrysotile Asbestos Fibres D.B.Warheit M.A.Hartsky C.J.Butterick S.R.Frame 9. Pulmonary Hyperreactivity to Industrial Pollutants J.Pauluhn 10. Mechanisms of Pulmonary Sensitization I.Kimber 11. Occupational Asthma Induced by Chemical Agents C.A.C.Pickering PART FOUR Biomarkers and risk assessment of industrial chemicals 12. Biomarkers and Risk Assessment K.Hemminki 13. Extrapolation of Toxicity Data and Assessment of Risk N.Fedtke 14. Molecular Approaches to Assess Cancer Risks A.S.Wright J.P.Aston N.J.van Sittert W.P.Watson 15. Evaluation of Toxicity to the Immune System H.-W.Vohr 16. New Strategies: the Use of Long-term Cultures of Hepatocytes in Toxicity Testing and Metabolism Studies of Chemical Products Other than Pharmaceuticals V.Rogiers M.Akrawi S.Coecke Y.Vandenberghe E.Shephard I.Phillips A.Vercruysse 117 129 138 149 157 158 167 180 197 207 PART FIVE Mechanisms of toxicity of industrial chemicals 222 17. Peroxisome Proliferation B.G.Lake R.J.Price 223 v
vi 18. Neurotoxicity Testing of Industrial Compounds: in vivo Markers and Mechanisms of Action K.J.van den Berg J.-B.P.Gramsbergen E.M.G.Hoogendijk J.H.C.M.Lammers W.S.Sloot B.M.Kulig 19. Endocrine Toxicology of the Thyroid for Industrial Compounds C.K.Atterwill S.P.Aylward 20. Testing and Evaluation for Reproductive Toxicity A.K.Palmer 238 255 280 PART SIX Toxicity of selected classes of industrial chemicals 300 21. Special Points in the Toxicity Assessment of Colorants (Dyes and Pigments) H.M.Bolt 301 22. Toxicology of Textile Chemicals D.Sedlak 309 23. Antioxidants and Light Stabilisers: Toxic Effects of 3,5-Dialkyl-hydroxyphenyl Propionic Acid Derivatives in the Rat and their Relevance for Human Safety Evaluation H.Thomas P.Dollenmeier E.Persohn H.Weideli F.Waechter 317 24. Toxicology of Surfactants: Molecular, Mechanistic and Regulatory Aspects W.Sterzel 339 PART SEVEN Controversial mechanistic and regulatory issues in the safety assessment of industrial chemicals 25. Low Dose of a Genotoxic Carcinogen does not ‘Cause’ Cancer; it Accelerates Spontaneous Carcinogenesis W.K.Lutz 26. Controversial Mechanistic and Regulatory Issues in Safety Assessment of Industrial Chemicals—an Industry Point of View H.-P.Gelbke 355 356 362 Index 373
Page 2 and 3: Toxicology of Industrial Compounds
Page 4 and 5: This edition published in the Taylo
Page 8 and 9: Preface A large number of chemical
Page 10 and 11: Contributors May Akrawi Department
Page 12 and 13: Beverly M.Kulig TNO Toxicology, Dep
Page 14 and 15: Richard A.Versen Schuller MTC, Heal
Page 16 and 17: 1 Biomonitoring and Absorption of I
Page 18 and 19: 4 BIOMONITORING AND ABSORPTION OF I
Page 24 and 25: 10 BIOMONITORING AND ABSORPTION OF
Page 26 and 27: 2 Toxicokinetics and Biodisposition
Page 28 and 29: 14 TOXICOKINETICS AND BIODISPOSITIO
Page 50 and 51: 3 Metabolic Activation of Industria
Page 52 and 53: 38 METABOLIC ACTIVATION OF INDUSTRI
Page 54 and 55: 40 METABOLIC ACTIVATION OF INDUSTRI
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42 METABOLIC ACTIVATION OF INDUSTRI
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4 Sizing up the Problem of Exposure
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46 SIZING UP THE PROBLEM OF EXPOSUR
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5 Metabolism of Reactive Chemicals
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62 METABOLISM OF REACTIVE CHEMICALS
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6 Methods for the Determination of
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74 METHODS FOR THE DETERMINATION OF
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PART THREE Pulmonary toxicology of
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92 CARCINOGENIC POTENTIAL OF MAN-MA
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100 CARCINOGENIC POTENTIAL OF MAN-M
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118 PULMONARY TOXICITY STUDIES WITH
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130 PULMONARY HYPERREACTIVITY TO IN
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10 Mechanisms of Pulmonary Sensitiz
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140 MECHANISMS OF PULMONARY SENSITI
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150 OCCUPATIONAL ASTHMA INDUCED BY
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12 Biomarkers and Risk Assessment K
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160 BIOMARKERS AND RISK ASSESSMENT
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168 EXTRAPOLATION OF TOXICITY DATA
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14 Molecular Approaches to Assess C
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182 MOLECULAR APPROACHES TO ASSESS
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198 EVALUATION OF TOXICITY TO THE I
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208 USE OF LONG-TERM CULTURES OF HE
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PART FIVE Mechanisms of toxicity of
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224 PEROXISOME PROLIFERATION normal
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226 PEROXISOME PROLIFERATION demons
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228 PEROXISOME PROLIFERATION Specie
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230 PEROXISOME PROLIFERATION intend
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232 PEROXISOME PROLIFERATION BENTLE
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234 PEROXISOME PROLIFERATION KRAUPP
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236 PEROXISOME PROLIFERATION POPP,
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18 Neurotoxicity Testing of Industr
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240 NEUROTOXICITY TESTING OF INDUST
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256 ENDOCRINE TOXICOLOGY OF THE THY
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20 Testing and Evaluation for Repro
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282 TESTING AND EVALUATION FOR REPR
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PART SIX Toxicity of selected class
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302 SPECIAL POINTS IN THE TOXICITY
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310 TOXICOLOGY OF TEXTILE CHEMICALS
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318 ANTIOXIDANTS AND LIGHT STABILIS
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340 TOXICOLOGY OF SURFACTANTS Inter
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342 TOXICOLOGY OF SURFACTANTS Figur
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344 TOXICOLOGY OF SURFACTANTS probl
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346 TOXICOLOGY OF SURFACTANTS nonio
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348 TOXICOLOGY OF SURFACTANTS and t
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350 TOXICOLOGY OF SURFACTANTS long-
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352 TOXICOLOGY OF SURFACTANTS COULS
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25 Low Dose of a Genotoxic Carcinog
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358 CARCINOGENESIS AT LOW DOSE Tabl
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360 CARCINOGENESIS AT LOW DOSE year
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26 Controversial Mechanistic and Re
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364 CONTROVERSIAL ISSUES IN SAFETY
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374 INDEX 2-bromo-glutathionyl 64 B
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376 INDEX Gas chromatography/mass s
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378 INDEX mRNA analysis 211 Mutagen
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380 INDEX Surfactants 338-55 acute
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Toxicology of Industrial Compounds

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