Toxicology of Industrial Compounds

Table 20.4 OECD 422: carbendazim, tabular summary
Notes:
a Malformations included hydrocephaly and misaligned tails.
pp=post partum
Bold type indicates treatment effects including macroscopic and microscopic
changes in testes and epididymides (an effect on spermatogenesis), an increased
duration of pregnancy, reduction in the number of females with live young and lower
values for litter size, litter weight and mean pup weight. The dosage related pattern
of response provides added emphasis, as does the observation of malformed
foetuses.
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litter weight and mean pup weight. The dosage related pattern of response
provides added emphasis, as does the observation of malformed foetuses.
With DEHP (Table 20.5) an effect on spermatogenesis is evident at 2000
mg kg −1 . Treatment at this dosage had to be withdrawn shortly after
mating to avoid further mortalities of the more susceptible females. There
is a marked reduction in the number of pregnancies. At lower dosages an
increased duration of pregnancy, reduced litter size and litter weight,
indicates an effect on the female and/or offspring. The higher mean pup
weights are consequent to the longer duration of pregnancy.
With cyclophosphamide (Table 20.6) female deaths at 3 and 4.5 mg kg −1
are attributable to treatment as, at 6.7 mg kg −1 , all females died. There was
a reduction in the number of females with young, litter size, litter weight
and mean pup weight, providing clear evidence of effects on the female and