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Toxicology of Industrial Compounds

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204 EVALUATION OF TOXICITY TO THE IMMUNE SYSTEM<br />

Table 15.3 Proposed amendment to the subdivision F guideline requirements to<br />

provide for an evaluation <strong>of</strong> the immunotoxicity <strong>of</strong> chemical pesticides<br />

proposals is a flow diagram for the evaluation <strong>of</strong> results from this basic<br />

study for hazard identification and conclusions drawn from it. This flow<br />

diagram, shown in Figure 15.1, could be helpful for the evaluation <strong>of</strong><br />

results obtained from incorporation <strong>of</strong> a basic immunotoxicity test battery<br />

into studies with routinely treated animals.<br />

References<br />

BASKETTER, D. et al., 1994, The identification with sensitising or<br />

immunosuppressive properties in routine toxicology, Food Chem. Toxicol. (in<br />

press).<br />

BOTHAM, P.A. et al., 1991, Skin sensitization—a critical review <strong>of</strong> predictive test<br />

methods in animals and men Food Chem. Toxicol, 29, 275–86.<br />

BÜHLER, E.V., 1965, Delayed contact hypersensitivity in the guinea pig, Arch.<br />

Dermatol. 91, 171.<br />

DEAN, J.H., PADARATHSINGH, M.L. and JERRELS, T.R., 1979, Assessment <strong>of</strong><br />

immunobiological effects induced by chemicals, drugs or food additives. I. Tier<br />

testing and screening approach, Drug Chem. Toxicol. 2, 5–17.<br />

ECETOC, 1990, Skin Sensitization Testing, Monograph No. 14, Brussels.

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