Toxicology of Industrial Compounds

1979), such as tetrazole or a sulphonamide moiety (Eacho et al., 1986;
Lock et al., 1989).
It should be noted that rodent liver peroxisome proliferators exhibit
marked compound potency differences. While potent peroxisome
proliferators include compounds developed as hypolipidaemic agents (e.g.
ciprofibrate, Wy-14,643), plasticisers such as DEHP are less potent and
chemicals such as acetylsalicylic acid are even less potent (Reddy et al.,
1986; Barber et al., 1987; Lake and Lewis, 1993). For example, in a 30day
feeding study, a similar magnitude of induction of palmitoyl-CoA
oxidation was observed in rats fed 0.001 per cent ciprofibrate and 0.5 per
cent DEHP diets, whereas for DEHA a dietary level of >1.0 per cent but