Toxicology of Industrial Compounds

296 TESTING AND EVALUATION FOR REPRODUCTIVE TOXICITY
Figure 20.7 Reproductive toxicity—selecting studies.
Figure 20.8 Pre- and post-natal (developmental toxicity) study.
mating through to termination of males after a minimum of 4 weeks of
treatment overall (Figure 20.9). Treatment of females continues to
implantation and they may be killed and examined at about day 13–15 of
pregnancy.
Alternatively, treatment of females can be continued beyond closure of
the palate or even through pregnancy (Figure 20.4). Foetuses can be