Toxicology of Industrial Compounds

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278 ENDOCRINE TOXICOLOGY OF THE THYROID OSHIMA, M. and WARD, J.M., 1984, Promotion of N-methyl-N-nitrosoureainduced thyroid tumours by iodine deficiency in F334/NCr rats, J. Nat. Cancer Inst., 73, 289–96. PARMA, J. et al., 1993, Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas, Nature, 365, 649–51. PETER, H.J., STUDER, H., FORSTER, R. and GERBER, H., 1982, The pathogenesis of ‘hot’ and ‘cold’ follicles in multinodular goitres, J. Clin. Endocrinol. Metal., 55, 941–6. PLIAM, N.B. and GOLDFINE, I.D., 1977, High affinity thyroid hormone binding sites on purified rat liver plasma membranes, Biochem. Biophys. Res. Comm., 19, 166–72. POOLE, A., BETTON, G.R., SALMON, G., SUTTON, T. and ATTERWILL, C.K., 1989, Comparative toxicology of temelastine; a novel non-sedating H 1 antagonist in the dog, rat and the monkey, Fundam. Appl. Toxicol, 14, 71–83. 14. POOLE, A., PRITCHARD, D., JONES, R.B., CATTO, L. and LEONARD, T., 1990, In vivo biliary excretion and in vitro cellular accumulation of thyroxine in rats or cultured rat hepatocytes treated with a novel histamine H 1 receptor antagonist, Arch. Toxicol, 64, 474–81. RAO, C.G., 1991, Mode of entry of steroid and thyroid hormones into cells, Mol. Cell Endocrinol., 21, 97–108. RIBELIN, W.E., 1984, The effects of drugs and chemicals upon the structure of the adrenal gland, Fundam. Appl. Toxicol, 4, 105–19. SAUNDERS, J.E., EIGENBURG, D.A., BRACHT, L.E., WANG, W.R. and VAN ZWEITEN, M.J., 1988, Thyroid and liver trophic changes in rat secondary to microsomal enzyme induction caused by an experimental leukotrien antagonist, (L-649,923), Toxicol. Appl. Pharmacol., 5, 378–87. SMEDS, S., PETERS, H.J., JORTSO, E., GERBER, H. and STUDER, H., 1987, Naturally occurring clones of cells with high intrinsic proliferation potential within the follicular epithelium of mouse thyroids, Cancer Res., 47, 1646–51. SMITH, P., WYNFORD-THOMAS, D., STRINGER, B.M.J. and WILLIAMS, E.D., 1986, Growth factor control of rat thyroid follicular cell proliferation, Endocrinology, 119, 1439–45. SORIMACHI, K. and ROBBINS, O., 1978, Uptake and metabolism of thyroid hormones by cultured monkey hepatocarcinoma cells. Effects of potassium cyanide and dinitrophenol, Biochim. Biophys. Acta, 542, 515–26. STORY, D.I., CARDONA, R.A. and LENGEN, M.R., 1993, Effect of dietary PCNB on circulating levels of T 3, T 4 and TSH in rats, The Toxicologist, 13(1), 1446. STRINGER, B.M.J., WYNFORD-THOMAS, D. and WILLIAMS, E.D., 1985, In vitro evidence for an intracellular mechanism limiting the thyroid follicular cell growth response to thyrotropin, Endocrinology, 116, 611–15. THOMAS, G.A. and WILLIAMS, E.D., 1991, Evidence for and possiblemechanisms of non-genotoxic carcinogenesis in the rodent thyroid, Mutat. Res., 248, 357– 70. THOMAS, G.A. and WILLIAMS, E.D., 1992, Production of thyroid tumours in mice by demethylating agents, Carcinogenesis, 13, 1039–42.
C.K.ATTERWILL AND S.P.AYLWARD 279 WILLIAMS, D.W., WYNFORD-THOMAS, D. and WILLIAMS, E.D., 1987, Human thyroid adenomas show escape from IGF-1 dependence for growth, Ann. Endocrinol., 48(2), 11. WYATT, I., GYTE, A., FOSTER, J.R., WILLIAMS, S.M. and ELCOMBE, C.R., 1993, Differences in the response of the rat and guinea pig liver and thyroid to hepatic enzyme inducers, Hum. Exp. Toxicol., 12(6), 561. WYNFORD-THOMAS, D., STRINGER, B.M. J. and WILLIAMS, E.D., 1982, Dissociation of growth and function in the rat thyroid during prolonged goitrogen administration, Acta Endocrinol., 101, 210–16. ZBINDEN, G. 1987, Assessment of hyperplastic and neoplastic lesions of the thyroid gland, TIPS (Dec., 1987), 8, 511–14.
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Toxicology of Industrial Compounds
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This edition published in the Taylo
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8. Pulmonary Toxicity Studies with
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Preface A large number of chemical
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Contributors May Akrawi Department
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Beverly M.Kulig TNO Toxicology, Dep
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Richard A.Versen Schuller MTC, Heal
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1 Biomonitoring and Absorption of I
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4 BIOMONITORING AND ABSORPTION OF I
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10 BIOMONITORING AND ABSORPTION OF
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2 Toxicokinetics and Biodisposition
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14 TOXICOKINETICS AND BIODISPOSITIO
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3 Metabolic Activation of Industria
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38 METABOLIC ACTIVATION OF INDUSTRI
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4 Sizing up the Problem of Exposure
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46 SIZING UP THE PROBLEM OF EXPOSUR
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5 Metabolism of Reactive Chemicals
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62 METABOLISM OF REACTIVE CHEMICALS
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6 Methods for the Determination of
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74 METHODS FOR THE DETERMINATION OF
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PART THREE Pulmonary toxicology of
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92 CARCINOGENIC POTENTIAL OF MAN-MA
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100 CARCINOGENIC POTENTIAL OF MAN-M
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118 PULMONARY TOXICITY STUDIES WITH
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130 PULMONARY HYPERREACTIVITY TO IN
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10 Mechanisms of Pulmonary Sensitiz
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140 MECHANISMS OF PULMONARY SENSITI
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150 OCCUPATIONAL ASTHMA INDUCED BY
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12 Biomarkers and Risk Assessment K
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160 BIOMARKERS AND RISK ASSESSMENT
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168 EXTRAPOLATION OF TOXICITY DATA
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14 Molecular Approaches to Assess C
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182 MOLECULAR APPROACHES TO ASSESS
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198 EVALUATION OF TOXICITY TO THE I
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208 USE OF LONG-TERM CULTURES OF HE
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PART FIVE Mechanisms of toxicity of
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224 PEROXISOME PROLIFERATION normal
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226 PEROXISOME PROLIFERATION demons
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328 ANTIOXIDANTS AND LIGHT STABILIS
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340 TOXICOLOGY OF SURFACTANTS Inter
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342 TOXICOLOGY OF SURFACTANTS Figur
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344 TOXICOLOGY OF SURFACTANTS probl
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346 TOXICOLOGY OF SURFACTANTS nonio
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348 TOXICOLOGY OF SURFACTANTS and t
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350 TOXICOLOGY OF SURFACTANTS long-
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352 TOXICOLOGY OF SURFACTANTS COULS
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25 Low Dose of a Genotoxic Carcinog
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358 CARCINOGENESIS AT LOW DOSE Tabl
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360 CARCINOGENESIS AT LOW DOSE year
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26 Controversial Mechanistic and Re
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364 CONTROVERSIAL ISSUES IN SAFETY
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374 INDEX 2-bromo-glutathionyl 64 B
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376 INDEX Gas chromatography/mass s
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378 INDEX mRNA analysis 211 Mutagen
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380 INDEX Surfactants 338-55 acute
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