Toxicology of Industrial Compounds

Post-radiolabelling technology 184
Prenatal effects 284, 285, 289
Production volume triggers 280, 281
Propylthiouracil (PTU) 260
Protein adducts 73, 74, 79, 81, 184–90
Protein-binding 258
Pulmonary cell proliferation 118, 124–7
Pulmonary hyperreactivity to industrial
pollutants 128–9
guinea-pig model 131–6
rat model 134–7
Pulmonary sensitization, mechanisms of
137–51
Pulmonary toxic effects
chrysotile asbestos fibres 116–30
para-aramid fibrils 116–30
Pulmonary uptake of organic solvents
3–5
Pyrethroid insecticides 238
Pyromellitic dianhydride (PMDA) 152
Quinone-thioethers 63
Quinones 63–6
Rad-equivalence values 192
Radioallergosorbent tests (RAST) 138
Radioimmunoassays 77
Reactive airways dysfunction syndrome
(RADS) 128, 148, 151, 153
Reactive chemicals, metabolism 60–71
Reactive compounds
adduct formation of 74
determination in unknown mixtures
83–6
determination of 71–88
interaction with cellular constituents
71–5
Reactive metabolites 71
Refractory ceramic fibres (RCFs) 91,
99–2
industrial hygiene studies 105
Repeated dose toxicity 281
Reproductive toxicity 279–298
detecting effects on males 293
evaluation for 282
interpretation/extrapolation of 296–
9
INDEX 379
labelling 296–9
manifestations of 291–4
methods for detecting effects on 282
overlap of 281
Respiratory allergic hypersensitivity
137
Restricted test systems 283
Rifampicin 322
Risk assessment 162–9, 166–84
and exposure profiles 362–68
approaches to 167–6
cancer 188–6
guidelines for 361
in vitro approach 207–13
mathematical procedures 369–3
non-threshold effects 368
peroxisome proliferation 229–5
phenolic antioxidants 321–5
physiologically based
pharmacokinetic (PBPK) models in.
See PBPK/PBTK models
textile chemicals 315
threshold effects 366–71
see also Safety assessment
RNA probes 211
Rock (stone) wool 91, 102–5
industrial hygiene studies 108
R-phrases 364
Safety assessment 361–74
benzotriazole-based light stabilisers
331–7
see also Risk assessment
Salmonella typhimurium 66
SHIELD system 149
Slag wool 91, 102–5
industrial hygiene studies 108
Solid phase assays 77
Sperm analysis 284
Spermatogenesis 284, 286, 288
Structure-activity databases 282
Structure-activity relationships,
surfactants 344
Styrene 38–38
Styrene oxide 38–38
Superoxide dismutase (SOD) 241
Surface markers 200