146 MECHANISMS OF PULMONARY SENSITIZATION KAROL, M.H., HAUTH, B.A., RILEY, E.J. and MAGRENI, C.M., 1981, Dermal contact with toluene diisocyanate (TDI) produces respiratory tract hypersensitivity in guinea pigs, <strong>Toxicology</strong> and Applied Pharmacology, 58, 221–30. KAROL, M.H., TOLLERUD, D.J., CAMPBELL, T.P., FABBRI, L., MAESTRELLI, P., SAETTA, M. and MAPP, C.E., 1994, Predictive value <strong>of</strong> airways hyperresponsiveness and circulating IgE for identifying types <strong>of</strong> responses to toluene diisocyanate inhalation challenge, American Journal <strong>of</strong> Respiratory and Critical Care Medicine, 149, 611–15. KAY, A.B., YING, S., VARNEY, V., GAGA, M., DURHAM, S.R., MOQBEL, R., WARDLAW, A.J. and HAMID, Q., 1991, Messenger RNA expression <strong>of</strong> the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5 and granulocyte/ macrophage colony stimulating factor, in allergen-induced last phase reactions in atopic subjects, Journal <strong>of</strong> Experimental Medicine, 173, 775–8. KEMENY, D.M., NOBLE, A., HOLMES, B.J. and DIAZ-SANCHEZ, D., 1994, Immune regulation: a new role for the CD8 + T cell, Immunology Today, 15, 107–10. KIMBER, I. and DEARMAN, R.J., 1993, Approaches to the identification and classification <strong>of</strong> chemical allergens in mice, Journal <strong>of</strong> Pharmacological and Toxicological Methods, 29, 11–16. KUHN, R., RAJEWSKY, K. and MULLER, W., 1991, Generation and analysis <strong>of</strong> interleukin-4 deficient mice, Science, 254, 707–10. MACCIA, C.A. BERNSTEIN, I.L., EMMETT, E.A. and BROOKS, S.M. 1976, In vitro demonstration <strong>of</strong> specific IgE in phthalic anhydride sensitivity, American Review <strong>of</strong> Respiratory Disease, 113, 701–4. MANETTI, R., GEROSA, F., GIUDIZI, M.G., BIAGIOTTI, R., PARRONCHI, P., PICCINNI, M-P., SAMPOGNARO, S., MAGGI, E., ROMAGNANI, S. and TRI NCHIERI, G., 1994, Interleukin 12 induces stable priming for interferon (IFN- ) production during differentiation <strong>of</strong> human T helper (Th) cells and transient IFN- production in established Th 2 cell clones, Journal <strong>of</strong> Experimental Medicine, 179, 1273–83. MOLLER, D.R., GALLAGHER, J.S., BERNSTEIN, D.I., WILCOX, T.G., BURROUGHS, H.E. and BERNSTEIN, I.L., 1985, Detection <strong>of</strong> IgE-mediated respiratory sensitization in workers exposed to hexahydrophthalic anhydride, Journal <strong>of</strong> Allergy and Clinical Immunology, 15, 663–72. MORRIS, S.C., MADDEN, K.B., ADAMOVICZ, J.J., GAUSE, W.C., HUBBARD, B.R., GATELY, M.K. and FINKELMAN, F.D., 1994, Effects <strong>of</strong> IL-12 on in vivo cytokine gene expression and Ig isotype selection, Journal <strong>of</strong> Immunology, 152, 1047–56. MOSMAN, T.R. and COFFMAN, R.L., 1989, Heterogeneity <strong>of</strong> cytokine secretion patterns and functions <strong>of</strong> helper T cells, Advances in Immunology, 46, 111– 47. MOSMANN, T.R., SCHUMACHER, J.H., STREET, N.F., BUDD, R., O’GARRA, A., FONG, T.A.T., BOND, M.W., MOORE, K.W.M., SHER, A. and FIORENTINO, D.F., 1991, Diversity <strong>of</strong> cytokine synthesis and function <strong>of</strong> mouse CD4 + T cells, Immunological Reviews, 123, 209–29. MURANKA, M., SUZUKI, S., KOIZUMI, K., TAKAFUJI, S., MIYAMOTO, T., IKEMURI, R. and TOKIWA, H., 1986, Adjuvant activity <strong>of</strong> diesel-exhaust
I.KIMBER 147 particulates for the production <strong>of</strong> IgE antibody in mice, Journal <strong>of</strong> Allergy and Clinical Immunology, 77, 616–23. MURDOCH, R.D., PEPYS, J. and HUGHES, E.G., 1986. IgE antibody responses to platinum group metals: a large scale refinery survey, British Journal <strong>of</strong> <strong>Industrial</strong> Medicine, 43, 37–43. NEMERY, B. and LENAERTS, L., 1993, Exposure to methylene diphenyl diisocyanate in coal mines, Lancet, 341, 318. NEWMAN TAYLOR, A.J., 1988, Occupational asthma, Postgraduate Medical Journal, 64, 505–10. NOBLE, A., STAYNOV, D.Z., DIAZ-SANCHEZ, D., LEE, T.J. and KEMENY, D. M., 1993, Elimination <strong>of</strong> IgE regulatory rat CD8 + T cells in vivo increases the co-ordinate expression <strong>of</strong> Th 2 cytokines IL-4, IL-5 and IL-10, Immunology, 80, 326–9. O’BRIEN, I.M., HARRIES, M.G., BURGE, P.S. and PEPYS, J., 1979, Toulene diisocyanate-induced asthma. 1. Reactions to TDI, MDI, HDI and histamine, Clinical Allergy, 9, 1–6. PARRONCHI, P., MACCHIA, D., PICCINI, M-P., BISWAS, P., SIMONELLI, C., MAGGI, E., RICCI, M., ANSARI, A.A. and ROMAGNANI, S., 1991, Allergen and bacterial antigen-specific T cell clones established from atopic donors show a different pr<strong>of</strong>ile <strong>of</strong> cytokine production, Proceedings <strong>of</strong> the National Academy <strong>of</strong> Sciences USA, 88, 4538–42. PENE, J., ROUSSET, F., BRIERE, F., CHRETIEN, I., PALIARD, X., BANCHEREAU, J., SPITS, H. and DE VRIES, J.E., 1988, IgE production by normal human B cells induced by alloreactive T cell clones is mediated by 11–4 and suppressed by IFN- , Journal <strong>of</strong> Immunology, 141, 1218–24. POWRIE, F., MENON, S. and COFFMAN, R.L., 1993, Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo, European Journal <strong>of</strong> Immunology, 23, 3043–9. QUIRCE, S., CUEVAS, M., OLAGUIBEL, J.M. and TABAR, A.I., 1994, Occupa tional asthma and immunological responses induced by inhaled carmine among employees at a factory making natural dyes, Journal <strong>of</strong> Allergy and Clinical Immunology, 93, 44–52. RATTRAY, N.J., BOTHAM, P.A., HEXT, P.M., WOODCOCK, D.R., FIELDING, I., DEARMAN, R.J. and KIMBER, I., 1994, Induction <strong>of</strong> respiratory hypersensitivity to diphenylmethane-4,4′-diisocyanate (MDI) in guinea pigs. Influence <strong>of</strong> route <strong>of</strong> exposure, <strong>Toxicology</strong>, 88, 15–30. RENZ, H., LACK, G., SALOGA, J., SCHWINZER, R., BRADLEY, K., LOADER, J., KUPFER, A., LARSEN, G.L. and GELFAND, E.W., 1994, Inhibition <strong>of</strong> IgE production and normalization <strong>of</strong> airways responsiveness by sensitized CD8 T cells in a mouse model <strong>of</strong> allergen-induced sensitization, Journal <strong>of</strong> Immunology, 152, 351–60. ROMAGNANI, S., 1991, Human TH1 and T H2 subsets: doubt no more, Immunology Today, 12, 256–7. SCHMITT, E., HOEHN, P., HUELS, C., GOEDERT, S., PALM, N., RUDE, E. and GERMANN, T., 1994, T helper type 1 development <strong>of</strong> naive CD4 + T cells requires the coordinate action <strong>of</strong> interleukin-12 and interferon- and is inhibited by transforming growth factor-β, European Journal <strong>of</strong> Immunology, 24, 793–8.
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Toxicology of Industrial Compounds
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This edition published in the Taylo
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8. Pulmonary Toxicity Studies with
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Preface A large number of chemical
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Contributors May Akrawi Department
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Beverly M.Kulig TNO Toxicology, Dep
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Richard A.Versen Schuller MTC, Heal
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1 Biomonitoring and Absorption of I
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4 BIOMONITORING AND ABSORPTION OF I
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6 BIOMONITORING AND ABSORPTION OF I
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8 BIOMONITORING AND ABSORPTION OF I
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10 BIOMONITORING AND ABSORPTION OF
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2 Toxicokinetics and Biodisposition
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14 TOXICOKINETICS AND BIODISPOSITIO
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16 TOXICOKINETICS AND BIODISPOSITIO
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18 TOXICOKINETICS AND BIODISPOSITIO
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20 TOXICOKINETICS AND BIODISPOSITIO
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22 TOXICOKINETICS AND BIODISPOSITIO
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24 TOXICOKINETICS AND BIODISPOSITIO
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26 TOXICOKINETICS AND BIODISPOSITIO
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28 TOXICOKINETICS AND BIODISPOSITIO
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30 TOXICOKINETICS AND BIODISPOSITIO
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32 TOXICOKINETICS AND BIODISPOSITIO
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34 TOXICOKINETICS AND BIODISPOSITIO
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3 Metabolic Activation of Industria
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38 METABOLIC ACTIVATION OF INDUSTRI
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40 METABOLIC ACTIVATION OF INDUSTRI
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42 METABOLIC ACTIVATION OF INDUSTRI
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4 Sizing up the Problem of Exposure
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46 SIZING UP THE PROBLEM OF EXPOSUR
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48 SIZING UP THE PROBLEM OF EXPOSUR
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50 SIZING UP THE PROBLEM OF EXPOSUR
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52 SIZING UP THE PROBLEM OF EXPOSUR
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54 SIZING UP THE PROBLEM OF EXPOSUR
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56 SIZING UP THE PROBLEM OF EXPOSUR
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58 SIZING UP THE PROBLEM OF EXPOSUR
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5 Metabolism of Reactive Chemicals
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62 METABOLISM OF REACTIVE CHEMICALS
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64 METABOLISM OF REACTIVE CHEMICALS
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66 METABOLISM OF REACTIVE CHEMICALS
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68 METABOLISM OF REACTIVE CHEMICALS
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70 METABOLISM OF REACTIVE CHEMICALS
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6 Methods for the Determination of
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74 METHODS FOR THE DETERMINATION OF
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76 METHODS FOR THE DETERMINATION OF
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78 METHODS FOR THE DETERMINATION OF
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80 METHODS FOR THE DETERMINATION OF
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82 METHODS FOR THE DETERMINATION OF
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84 METHODS FOR THE DETERMINATION OF
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86 METHODS FOR THE DETERMINATION OF
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88 METHODS FOR THE DETERMINATION OF
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PART THREE Pulmonary toxicology of
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92 CARCINOGENIC POTENTIAL OF MAN-MA
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94 CARCINOGENIC POTENTIAL OF MAN-MA
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196 MOLECULAR APPROACHES TO ASSESS
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198 EVALUATION OF TOXICITY TO THE I
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200 EVALUATION OF TOXICITY TO THE I
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202 EVALUATION OF TOXICITY TO THE I
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204 EVALUATION OF TOXICITY TO THE I
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206 EVALUATION OF TOXICITY TO THE I
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208 USE OF LONG-TERM CULTURES OF HE
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210 USE OF LONG-TERM CULTURES OF HE
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212 USE OF LONG-TERM CULTURES OF HE
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214 USE OF LONG-TERM CULTURES OF HE
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216 USE OF LONG-TERM CULTURES OF HE
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218 USE OF LONG-TERM CULTURES OF HE
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220 USE OF LONG-TERM CULTURES OF HE
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PART FIVE Mechanisms of toxicity of
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224 PEROXISOME PROLIFERATION normal
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226 PEROXISOME PROLIFERATION demons
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228 PEROXISOME PROLIFERATION Specie
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230 PEROXISOME PROLIFERATION intend
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232 PEROXISOME PROLIFERATION BENTLE
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234 PEROXISOME PROLIFERATION KRAUPP
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236 PEROXISOME PROLIFERATION POPP,
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18 Neurotoxicity Testing of Industr
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240 NEUROTOXICITY TESTING OF INDUST
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242 NEUROTOXICITY TESTING OF INDUST
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244 NEUROTOXICITY TESTING OF INDUST
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246 NEUROTOXICITY TESTING OF INDUST
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248 NEUROTOXICITY TESTING OF INDUST
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250 NEUROTOXICITY TESTING OF INDUST
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252 NEUROTOXICITY TESTING OF INDUST
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254 NEUROTOXICITY TESTING OF INDUST
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256 ENDOCRINE TOXICOLOGY OF THE THY
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258 ENDOCRINE TOXICOLOGY OF THE THY
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260 ENDOCRINE TOXICOLOGY OF THE THY
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262 ENDOCRINE TOXICOLOGY OF THE THY
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264 ENDOCRINE TOXICOLOGY OF THE THY
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266 ENDOCRINE TOXICOLOGY OF THE THY
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268 ENDOCRINE TOXICOLOGY OF THE THY
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270 ENDOCRINE TOXICOLOGY OF THE THY
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272 ENDOCRINE TOXICOLOGY OF THE THY
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274 ENDOCRINE TOXICOLOGY OF THE THY
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276 ENDOCRINE TOXICOLOGY OF THE THY
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278 ENDOCRINE TOXICOLOGY OF THE THY
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20 Testing and Evaluation for Repro
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282 TESTING AND EVALUATION FOR REPR
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284 TESTING AND EVALUATION FOR REPR
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286 TESTING AND EVALUATION FOR REPR
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288 TESTING AND EVALUATION FOR REPR
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290 TESTING AND EVALUATION FOR REPR
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292 TESTING AND EVALUATION FOR REPR
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294 TESTING AND EVALUATION FOR REPR
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296 TESTING AND EVALUATION FOR REPR
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298 TESTING AND EVALUATION FOR REPR
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PART SIX Toxicity of selected class
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302 SPECIAL POINTS IN THE TOXICITY
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304 SPECIAL POINTS IN THE TOXICITY
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306 SPECIAL POINTS IN THE TOXICITY
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308 SPECIAL POINTS IN THE TOXICITY
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310 TOXICOLOGY OF TEXTILE CHEMICALS
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312 TOXICOLOGY OF TEXTILE CHEMICALS
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314 TOXICOLOGY OF TEXTILE CHEMICALS
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316 TOXICOLOGY OF TEXTILE CHEMICALS
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318 ANTIOXIDANTS AND LIGHT STABILIS
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320 ANTIOXIDANTS AND LIGHT STABILIS
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322 ANTIOXIDANTS AND LIGHT STABILIS
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324 ANTIOXIDANTS AND LIGHT STABILIS
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326 ANTIOXIDANTS AND LIGHT STABILIS
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328 ANTIOXIDANTS AND LIGHT STABILIS
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330 ANTIOXIDANTS AND LIGHT STABILIS
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332 ANTIOXIDANTS AND LIGHT STABILIS
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334 ANTIOXIDANTS AND LIGHT STABILIS
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336 ANTIOXIDANTS AND LIGHT STABILIS
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338 ANTIOXIDANTS AND LIGHT STABILIS
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340 TOXICOLOGY OF SURFACTANTS Inter
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342 TOXICOLOGY OF SURFACTANTS Figur
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344 TOXICOLOGY OF SURFACTANTS probl
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346 TOXICOLOGY OF SURFACTANTS nonio
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348 TOXICOLOGY OF SURFACTANTS and t
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350 TOXICOLOGY OF SURFACTANTS long-
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352 TOXICOLOGY OF SURFACTANTS COULS
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354
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25 Low Dose of a Genotoxic Carcinog
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358 CARCINOGENESIS AT LOW DOSE Tabl
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360 CARCINOGENESIS AT LOW DOSE year
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26 Controversial Mechanistic and Re
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364 CONTROVERSIAL ISSUES IN SAFETY
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366 CONTROVERSIAL ISSUES IN SAFETY
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368 CONTROVERSIAL ISSUES IN SAFETY
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370 CONTROVERSIAL ISSUES IN SAFETY
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372 CONTROVERSIAL ISSUES IN SAFETY
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374 INDEX 2-bromo-glutathionyl 64 B
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376 INDEX Gas chromatography/mass s
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378 INDEX mRNA analysis 211 Mutagen
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380 INDEX Surfactants 338-55 acute