Toxicology of Industrial Compounds

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380 INDEX Surfactants 338–55 acute toxicity 348–1 biochemical properties 338–5 carcinogenicity 350 chronic toxicity 349 embryotoxicity 350 excretion 347–50 interactions with enzymes 341–5 interactions with membranes 339 interactions with proteins 339–3 intestinal absorption 347–50 local effects 342–48 metabolism 347–50 mucous membrane compatibility 345 mutagenicity 349–2 oral toxicity 348 percutaneous absorptions 346–9 sensitization 345–8 skin compatibility 342–7 structure/activity relationships 344 systemic effects 348 toxicokinetics 346–50 Surveillance of Work-related and Occupational Respiratory Disease Project (SWORD) 148 Synaptophysin 242 Systemic bioavailability of colorants 301 Systemic toxicity assessment 285 Target dose determination 188–4 Temelastine 271 272, 273 2-tert-buty1–4-methoxyphenol (BHA) 316 Testosterone 212 Tetrachloroethane 7 Tetrachloroethene 8, 7 Tetrachlorophthalic anhydride (TCPA) 152, 153 Textile chemicals 308–18 finishing plant 309–13 handling and processing 312–18 irritant properties 311, 312 new developments regarding toxicology 309 oral toxicity 310 process off-gas 315 risk assessment 315 temperature effects 311 toxicological profile 311 toxicology assessment needs 315 Thalidomide 291 T helper (Th) cells 140–5 Thioethers 21–3 Threshold effects classification 364–9 risk assessment 366–71 Thyroglobulin (TBG) 258, 260 Thyroid endocrine toxicology 254–80 tumours of 256 Thyroid binding pre-albumin (TBPA) 258–2 Thyroid follicles 260 Thyroid follicular capability 262 Thyroid follicular cell hyperplasia and neoplasia, pathobiology of 262–7 Thyroid function control of 258 perturbation of 256–60 Thyroid hormones 258, 260, 318–4 Thyroid lesions, pathobiology of 258 Thyroid neoplasia 262, 321 Thyroid stimulating hormone (TSH) 258, 260, 262, 263, 265, 320, 321, 322 Thyroid toxicity 256 via H-P-T-L axis 265–76 Thyroid tumorigenesis 264 Thyrotrophin releasing hormone (TRH) 258, 262 Thyrotropin 318–4 Thyroxine 260, 269 accumulation 271, 273 clearance of 267–76 T lymphocytes 142 Toluene 241 2,4- and 2,6-toluene diisocyanate (TDI) 151 Toxicity, and metabolism 206–12 Toxicity tests, EC annex VII and VIII 280 Toxicodynamic interactions 20 Toxicokinetic interactions 20
Toxicokinetic parameters 16 Toxicokinetics, principles of 15 Transition metals 246 Trichloroacetic acid (TCA) 28, 29 Trichloroethane 7, 8 Trichloroethylene (TRI) 26–31 effects related to 26–31 hepatocarcinogenicity induced by 28 oxidative metabolism 28, 29 2,5,6-trichloro-3-glutathion-S-yl) hydroquinone 64 Triethyl lead 241 tri-(2-ethylhexyl)trimellitate) 223 Trimellitic anhydride (TMA) 152, 153 Trimethyltin (TMT) 241–6 Tumour incidence 189–5 Two generation studies 291–5 alternatives to 295–8 UDP-glucuronosyltransferase 321, 327, 329 UDP-glucuronyltransferase (UDP-GT) 213, 260, 267, 271, 274 University of Pittsburgh study 91, 92 Urinary excretion mercapturic acids 15, 25 xenobiotics 16–18 US Environmental Protection Agency 91 US-NTP study 200 Veterinary medicinal chemicals 202 Vinyl chloride 36–9 Western blotting 211 World Health Organization (WHO) 91 Xenobiotic-induced endocrine dysfunction 254 Xenobiotics 11 assessment of long-term toxicity 207 biological effects 14 disposition of 12–15 overall exposure to 20 urinary excretion of 16–18 INDEX 381
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Toxicology of Industrial Compounds
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This edition published in the Taylo
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8. Pulmonary Toxicity Studies with
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Preface A large number of chemical
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Contributors May Akrawi Department
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Beverly M.Kulig TNO Toxicology, Dep
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Richard A.Versen Schuller MTC, Heal
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1 Biomonitoring and Absorption of I
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4 BIOMONITORING AND ABSORPTION OF I
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10 BIOMONITORING AND ABSORPTION OF
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2 Toxicokinetics and Biodisposition
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14 TOXICOKINETICS AND BIODISPOSITIO
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3 Metabolic Activation of Industria
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38 METABOLIC ACTIVATION OF INDUSTRI
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4 Sizing up the Problem of Exposure
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46 SIZING UP THE PROBLEM OF EXPOSUR
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5 Metabolism of Reactive Chemicals
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62 METABOLISM OF REACTIVE CHEMICALS
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6 Methods for the Determination of
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74 METHODS FOR THE DETERMINATION OF
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PART THREE Pulmonary toxicology of
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92 CARCINOGENIC POTENTIAL OF MAN-MA
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100 CARCINOGENIC POTENTIAL OF MAN-M
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118 PULMONARY TOXICITY STUDIES WITH
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130 PULMONARY HYPERREACTIVITY TO IN
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10 Mechanisms of Pulmonary Sensitiz
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140 MECHANISMS OF PULMONARY SENSITI
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150 OCCUPATIONAL ASTHMA INDUCED BY
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12 Biomarkers and Risk Assessment K
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160 BIOMARKERS AND RISK ASSESSMENT
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168 EXTRAPOLATION OF TOXICITY DATA
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14 Molecular Approaches to Assess C
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182 MOLECULAR APPROACHES TO ASSESS
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198 EVALUATION OF TOXICITY TO THE I
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208 USE OF LONG-TERM CULTURES OF HE
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PART FIVE Mechanisms of toxicity of
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224 PEROXISOME PROLIFERATION normal
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226 PEROXISOME PROLIFERATION demons
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228 PEROXISOME PROLIFERATION Specie
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230 PEROXISOME PROLIFERATION intend
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232 PEROXISOME PROLIFERATION BENTLE
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234 PEROXISOME PROLIFERATION KRAUPP
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236 PEROXISOME PROLIFERATION POPP,
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18 Neurotoxicity Testing of Industr
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240 NEUROTOXICITY TESTING OF INDUST
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256 ENDOCRINE TOXICOLOGY OF THE THY
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20 Testing and Evaluation for Repro
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282 TESTING AND EVALUATION FOR REPR
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PART SIX Toxicity of selected class
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302 SPECIAL POINTS IN THE TOXICITY
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310 TOXICOLOGY OF TEXTILE CHEMICALS
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318 ANTIOXIDANTS AND LIGHT STABILIS
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Page 344 and 345: 330 ANTIOXIDANTS AND LIGHT STABILIS
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Page 360 and 361: 346 TOXICOLOGY OF SURFACTANTS nonio
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Page 370 and 371: 25 Low Dose of a Genotoxic Carcinog
Page 372 and 373: 358 CARCINOGENESIS AT LOW DOSE Tabl
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Page 376 and 377: 26 Controversial Mechanistic and Re
Page 378 and 379: 364 CONTROVERSIAL ISSUES IN SAFETY
Page 388 and 389: 374 INDEX 2-bromo-glutathionyl 64 B
Page 390 and 391: 376 INDEX Gas chromatography/mass s
Page 392 and 393: 378 INDEX mRNA analysis 211 Mutagen
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Toxicology of Industrial Compounds

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