Toxicology of Industrial Compounds

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374 INDEX 2-bromo-glutathionyl 64 Bromohydroquinone 63–5 o-bromophenol 63 Bronchial challenge tests 149 Bronchial hyperreactivity 151 Bronchoalveolar lavage 117, 123 1,3-butadiene PBPK/PBTK model 16 physiologically based toxicokinetic modeling 31–3 2-butoxyacetic acid (BAA) 172–80 2-butoxyethanol, PBPK/PBTK model 166–4, 172–80 Calcium 245–9, 250, 267 Cancer risk ‘absolute’ 191 assessment 188–6 definitions 356 management of 181 Carbamazepine 322 Carbendazim 285–8 Carbon disulphide 238 Carcinogen(esis) 179–6, 356 azo colorants 301–6 DNA-reactive 356 dose-response relationship in 356 epidemiological approaches to detect and identify 183–9 genotoxic 181–8 identification of 183–93 peroxisome proliferation 224–30 role of CYPs in activation and detoxication of 206 spontaneous process 356, 357–3 surfactants 350 Carcinogenic potency 181 Carcinogenic Substances Regulation 301 Catabolic metabolism 260 Catalase 241 Cell-mediated immune responses in chemical respiratory allergy 142–6 Cellular nucleophiles 73 Cerebral calcium accumulation 240 Chemical pesticides, immunotoxicity of 203 Chemical respiratory allergy, cellmediated immune responses in 142–6 Chlordecone 241 Chlorinated solvents 223 Chloroform 38–1 Chromates 301 Chrysotile asbestos fibres pulmonary toxic effects 116–30 size-separation methods 118–3 Classification systems 368–3 Color Index 301 Colorants (dyes and pigments) 301–10 regulatory aspects (FRG) 304–7 Cosmetics 208 Cultured porcine thyrocytes 261 Cyclophosphamide 286–90 Cytochrome P-450 (CYP) 15, 60, 74, 206–15, 318, 327, 332 Cytokine products of murine Th 1 and Th 2 cells 141 Cytokines 140 Dangerous compounds 208 1,2-DCV-Cys 29, 31 DCV-G 29 1,2-DCV-G 29, 31 1,2-DCV-Nac 29 2,2-DCV-Nac 29 Dermal uptake of organic solvents 5–7 Detoxication, enzymes involved in 60–4 Developmental neurotoxins 247–2 Diagonal radioactive zones (DRZ) 158 Diarylide pigments 81–3 1,2-dibromoethane 40, 65–8 3,3′-dichlorobenzidine (DCB) 81–3, 301, 303 1,2-dichloroethane 65–8 2,5-dichloro-3-(glutathion-S-y1) hydroquinone 64 Dichloromethane 39 1,3-dichloropropene (DCP) 21–3 S-(l,2-dichlorovinyl)glutathione. See 1, 2-DCV-G di-(2-ethylhexyl)adipate (DEHA) 223, 224, 227, 229–4 di-(2-ethylhexyl)phthalate (DEHP) 223, 224, 227–4, 286, 287
5α-dihydrotestosterone 212 Diisocyanate asthma 151 di-(isodecyl)phthalate 223 3,3′-dimethoxybenzine 301 3,3′-dimethylbenzidine 301 Dioctyl phthalate 152 Diphenylhydantoin 322 2,6-di-tert-butyl-4-methyl phenol (BHT) 316–20 DNA adducts 74, 77–81, 83, 84, 158, 159–9, 183–91, 189, 224 immunoenrichment of 185–2 DNA binding 60 DNA damage 183, 192, 208, 356 endogenous 356–1 exogenous 357–3 DNA reactions 73 DNA-reactive carcinogens 356 dose-response curve 356 DNA repair 192 DNA replication 180, 192, 357 DNA synthesis 227, 230 Dopamine 246 Dose determination 188 Dose-response relationship and exposure profiles 362–68 DNA-reactive carcinogens 356 in carcinogenesis 356 low-dose range 190 DTH reactions 196 Dyes. See Colorants (dyes and pigments) EC annex VII and VIII toxicity tests 280 ECETOC 202 EDB, conjugation in rats and man 67 Electrophilic agents 60, 71 Electrophilic centres 72 Electrophilic compounds, examples of 72 Electrophilic metabolites 60 Embryotoxicity tests 289–3 Emulsifiers 312 Endocrine dysfunction, xenobioticinduced 254 INDEX 375 Endocrine toxicity, classification of 254– 59 Endocrine toxicology, thyroid 254–80 Entire mammalian tests 283 Environmental exposure 363 Environmental monitoring (EM) 19–1 Epoxide hydrolases (EH) 60 Equivalent radiation dose concept 192– 8 Ethanol 241 5-ethoxy-1,2,4-thiadiazole-3-carboxylic acid (ET-CA) 25–7 Ethylene glycol methyl ether (EGME) 286–91 Etridiazol, disposition of 25–7 European Union (EU) 167 Exposure profiles 362–68 Fatty amines 312 FDA Segment I study for medicines 283 Fecundity tests 284 Fertility and embryotoxicity 285 toxicity 281 Fibre aerosols 97 Fibre glass 91, 99–4 airborne levels in workplace 109 industrial hygiene studies 105–10 lung fibre levels in workers 110 Fibre recovery from lung tissue 118 Fischer 344 study (Kimber-White) 198– 4 Flame retardant 312–18 Flavin-containing monooxygenase (FMO) 211–16 Fluoranthene-DNA adducts 187 Foetal abnormalities 291 Food additives 208 Food and Agriculture Organization 208 Fotemustine 46, 47 Free radical formation 240–4, 246 Full scale testing 288–1 Furazolidone 68 Gas chromatography (GC) 74, 76, 81
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Toxicology of Industrial Compounds
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This edition published in the Taylo
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8. Pulmonary Toxicity Studies with
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Preface A large number of chemical
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Contributors May Akrawi Department
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Beverly M.Kulig TNO Toxicology, Dep
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Richard A.Versen Schuller MTC, Heal
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1 Biomonitoring and Absorption of I
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4 BIOMONITORING AND ABSORPTION OF I
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10 BIOMONITORING AND ABSORPTION OF
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2 Toxicokinetics and Biodisposition
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14 TOXICOKINETICS AND BIODISPOSITIO
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3 Metabolic Activation of Industria
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38 METABOLIC ACTIVATION OF INDUSTRI
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4 Sizing up the Problem of Exposure
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46 SIZING UP THE PROBLEM OF EXPOSUR
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5 Metabolism of Reactive Chemicals
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62 METABOLISM OF REACTIVE CHEMICALS
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6 Methods for the Determination of
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74 METHODS FOR THE DETERMINATION OF
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PART THREE Pulmonary toxicology of
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92 CARCINOGENIC POTENTIAL OF MAN-MA
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100 CARCINOGENIC POTENTIAL OF MAN-M
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118 PULMONARY TOXICITY STUDIES WITH
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130 PULMONARY HYPERREACTIVITY TO IN
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10 Mechanisms of Pulmonary Sensitiz
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140 MECHANISMS OF PULMONARY SENSITI
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150 OCCUPATIONAL ASTHMA INDUCED BY
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12 Biomarkers and Risk Assessment K
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160 BIOMARKERS AND RISK ASSESSMENT
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168 EXTRAPOLATION OF TOXICITY DATA
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14 Molecular Approaches to Assess C
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182 MOLECULAR APPROACHES TO ASSESS
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198 EVALUATION OF TOXICITY TO THE I
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208 USE OF LONG-TERM CULTURES OF HE
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PART FIVE Mechanisms of toxicity of
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224 PEROXISOME PROLIFERATION normal
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226 PEROXISOME PROLIFERATION demons
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228 PEROXISOME PROLIFERATION Specie
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230 PEROXISOME PROLIFERATION intend
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232 PEROXISOME PROLIFERATION BENTLE
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234 PEROXISOME PROLIFERATION KRAUPP
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236 PEROXISOME PROLIFERATION POPP,
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18 Neurotoxicity Testing of Industr
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240 NEUROTOXICITY TESTING OF INDUST
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256 ENDOCRINE TOXICOLOGY OF THE THY
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20 Testing and Evaluation for Repro
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282 TESTING AND EVALUATION FOR REPR
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PART SIX Toxicity of selected class
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302 SPECIAL POINTS IN THE TOXICITY
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310 TOXICOLOGY OF TEXTILE CHEMICALS
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318 ANTIOXIDANTS AND LIGHT STABILIS
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Page 338 and 339: 324 ANTIOXIDANTS AND LIGHT STABILIS
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Page 376 and 377: 26 Controversial Mechanistic and Re
Page 378 and 379: 364 CONTROVERSIAL ISSUES IN SAFETY
Page 390 and 391: 376 INDEX Gas chromatography/mass s
Page 392 and 393: 378 INDEX mRNA analysis 211 Mutagen
Page 394 and 395: 380 INDEX Surfactants 338-55 acute
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Toxicology of Industrial Compounds

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