Toxicology of Industrial Compounds

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204 EVALUATION OF TOXICITY TO THE IMMUNE SYSTEM Table 15.3 Proposed amendment to the subdivision F guideline requirements to provide for an evaluation of the immunotoxicity of chemical pesticides proposals is a flow diagram for the evaluation of results from this basic study for hazard identification and conclusions drawn from it. This flow diagram, shown in Figure 15.1, could be helpful for the evaluation of results obtained from incorporation of a basic immunotoxicity test battery into studies with routinely treated animals. References BASKETTER, D. et al., 1994, The identification with sensitising or immunosuppressive properties in routine toxicology, Food Chem. Toxicol. (in press). BOTHAM, P.A. et al., 1991, Skin sensitization—a critical review of predictive test methods in animals and men Food Chem. Toxicol, 29, 275–86. BÜHLER, E.V., 1965, Delayed contact hypersensitivity in the guinea pig, Arch. Dermatol. 91, 171. DEAN, J.H., PADARATHSINGH, M.L. and JERRELS, T.R., 1979, Assessment of immunobiological effects induced by chemicals, drugs or food additives. I. Tier testing and screening approach, Drug Chem. Toxicol. 2, 5–17. ECETOC, 1990, Skin Sensitization Testing, Monograph No. 14, Brussels.
Figure 15.1 Flow diagram (taken from the ECETOC monograph: Immunotoxicity). H.-W.VOHR 205 ECETOC, 1994, Immunotoxicity: hazard identification and risk assessment, Monograph No. 21, Brussels. EEC, 1991, Annex to directive 81/852/EEC—Note of guidance, 22.
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Toxicology of Industrial Compounds
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This edition published in the Taylo
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8. Pulmonary Toxicity Studies with
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Preface A large number of chemical
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Contributors May Akrawi Department
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Beverly M.Kulig TNO Toxicology, Dep
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Richard A.Versen Schuller MTC, Heal
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1 Biomonitoring and Absorption of I
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4 BIOMONITORING AND ABSORPTION OF I
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10 BIOMONITORING AND ABSORPTION OF
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2 Toxicokinetics and Biodisposition
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14 TOXICOKINETICS AND BIODISPOSITIO
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3 Metabolic Activation of Industria
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38 METABOLIC ACTIVATION OF INDUSTRI
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4 Sizing up the Problem of Exposure
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46 SIZING UP THE PROBLEM OF EXPOSUR
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5 Metabolism of Reactive Chemicals
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62 METABOLISM OF REACTIVE CHEMICALS
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6 Methods for the Determination of
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74 METHODS FOR THE DETERMINATION OF
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PART THREE Pulmonary toxicology of
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92 CARCINOGENIC POTENTIAL OF MAN-MA
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100 CARCINOGENIC POTENTIAL OF MAN-M
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118 PULMONARY TOXICITY STUDIES WITH
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130 PULMONARY HYPERREACTIVITY TO IN
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10 Mechanisms of Pulmonary Sensitiz
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140 MECHANISMS OF PULMONARY SENSITI
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150 OCCUPATIONAL ASTHMA INDUCED BY
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152 OCCUPATIONAL ASTHMA INDUCED BY
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Page 172 and 173: 12 Biomarkers and Risk Assessment K
Page 174 and 175: 160 BIOMARKERS AND RISK ASSESSMENT
Page 182 and 183: 168 EXTRAPOLATION OF TOXICITY DATA
Page 194 and 195: 14 Molecular Approaches to Assess C
Page 196 and 197: 182 MOLECULAR APPROACHES TO ASSESS
Page 212 and 213: 198 EVALUATION OF TOXICITY TO THE I
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Page 252 and 253: 18 Neurotoxicity Testing of Industr
Page 254 and 255: 240 NEUROTOXICITY TESTING OF INDUST
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254 NEUROTOXICITY TESTING OF INDUST
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256 ENDOCRINE TOXICOLOGY OF THE THY
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20 Testing and Evaluation for Repro
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282 TESTING AND EVALUATION FOR REPR
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PART SIX Toxicity of selected class
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302 SPECIAL POINTS IN THE TOXICITY
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310 TOXICOLOGY OF TEXTILE CHEMICALS
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318 ANTIOXIDANTS AND LIGHT STABILIS
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340 TOXICOLOGY OF SURFACTANTS Inter
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342 TOXICOLOGY OF SURFACTANTS Figur
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344 TOXICOLOGY OF SURFACTANTS probl
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346 TOXICOLOGY OF SURFACTANTS nonio
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348 TOXICOLOGY OF SURFACTANTS and t
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350 TOXICOLOGY OF SURFACTANTS long-
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352 TOXICOLOGY OF SURFACTANTS COULS
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354
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25 Low Dose of a Genotoxic Carcinog
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358 CARCINOGENESIS AT LOW DOSE Tabl
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360 CARCINOGENESIS AT LOW DOSE year
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26 Controversial Mechanistic and Re
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364 CONTROVERSIAL ISSUES IN SAFETY
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374 INDEX 2-bromo-glutathionyl 64 B
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376 INDEX Gas chromatography/mass s
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378 INDEX mRNA analysis 211 Mutagen
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380 INDEX Surfactants 338-55 acute
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