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Toxicology of Industrial Compounds

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very low, areas where neurotoxic events take place are easily identified and<br />

quantified by autoradiographic or scintillation counting procedures.<br />

Finally, the role <strong>of</strong> oxidative stress by free radical formation in the<br />

nervous system merits further studies since it may open up possibilities for<br />

providing a biomarker that is linked to a mechanism <strong>of</strong> neurotoxic action.<br />

Acknowledgements<br />

The author is grateful for unpublished information provided by Dr Didema<br />

de Groot on neuropathology, by Dennis C.Morse, MSc and the students<br />

Wendelien Wesseling and Annemiek Plug, Agricultural University<br />

Wageningen, on developmental effects <strong>of</strong> PCBs; and for expert technical<br />

assistance by Alita van der Sluijs-Gelling.<br />

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