Synthèse de composés organométalliques et évaluation de leurs activités biologiques....

Summary
Organometallics have shown interesting applications during the last ten years, due to their
multiple biological activities and their potential use as biological probes, green catalysis and
therapeutic agents.
Ferrocene is known to be stable chemically and thermally and its addition in many drugs has
increased their biological activities (anti-tumourals such as ferrocifen, antibiotics such as
ferrocenyl-penecillin, antifungals such as ferrocen-fluconazol).
While the use of ferrocene is patented as a fertilizer and for the prevention and treatment of
iron deficiency in plants, only a few ferrocene derivatives have been studied for their
application in agriculture .
Starting from the idea of an analogy in tumour processes between crops and animals and due
to some multifunctional therapeutic compounds (anti-tumour, antibiotics, antifungal….), the
aim of the present thesis was the synthesis of organometallic molecules and their common
use in plant and animal therapies. Moreover, in order to improve their solubility and facilitate
their use, these synthetic compounds were converted to sugar derivatives (such as
ferrociphenols) or salt citrate derivatives (such as amino compounds).
The different compounds obtained were assayed against the MDA-MB-231 tumour cell line,
crown gall disease and against different pathogenic microbes affecting crops. We have shown
that the amino-tamoxifen analogues, organic or ferrocenic, were efficient against both tumour
and microbial cells. These compounds could be used in phytohealth monitoring due to their
ramarquable activity against olive tree microbial pathogens compared to many other standard
compounds.
Key words: Organometallics, Ferrocene, Tamoxifen, MDA-MB-231, crown gall,
antimicrobial, antitumour.