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résumés des cours et travaux - Collège de France

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LES ÉQUIPES ACCUEILLIES AU COLLÈGE DE FRANCE 959<br />

récepteur 5-HT 1A perm<strong>et</strong>tant ainsi à la nicotine d’activer les neurones sérotoninergiques<br />

(6). Enfin, l’utilisation <strong>de</strong> souris dépourvues <strong>de</strong> récepteurs μ-opioï<strong><strong>de</strong>s</strong>,<br />

confiées à l’équipe par Brigitte Kieffer (Strasbourg), a permis à Emilie Douc<strong>et</strong>, au<br />

<strong>cours</strong> <strong>de</strong> son stage <strong>de</strong> M2, <strong>de</strong> montrer que le découplage induit par l’éthanol<br />

nécessite la stimulation <strong><strong>de</strong>s</strong> récepteurs μ-opioï<strong><strong>de</strong>s</strong>, ce qui confirme la convergence,<br />

déjà constatée en clinique, entre les eff<strong>et</strong>s addictifs <strong>de</strong> l’éthanol <strong>et</strong> celle <strong><strong>de</strong>s</strong><br />

opiacés.<br />

Equipe Tronche : publications 2007-2008<br />

Stress and addiction, i<strong>de</strong>ntification of a specific neuronal cell-type for glucocorticoid<br />

receptor-induced facilitation of cocaine seeking. F. Ambroggi A., M. Turiault M., Au<strong>de</strong><br />

Mil<strong>et</strong> A., V. Deroche-Gamon<strong>et</strong>, S. Parnau<strong>de</strong>au, E. Balado, T. Lemberger, G. Schütz,<br />

M. Lazar, M. Marinelli, P.V. Piazza, F. Tronche. Soumis.<br />

Conditional inactivation of androgen receptor gene in the nervous system impairs<br />

masculine behaviors and androgen feedback on LH release. Raskin K., <strong>de</strong> Gendt K.,<br />

Duittoz A., Verhoeven G., Tronche F., Mhaouty-Kodja S. En révision.<br />

Decaens T., Godard C., <strong>de</strong> Reyniès A., Rickman D.S., Tronche F., Couty J.P.,<br />

Perr<strong>et</strong> C., Colnot S. Stabilization of b<strong>et</strong>a-catenin affects mouse embryonic liver growth<br />

and hepatoblast fate. Hepatology, 47 : 247-58.<br />

Tronche F. Corticosteroid receptor genes : functional dissection in mice. In : Encyclopedia<br />

of Stress, B. McEwen, G. Chroussos, Ron <strong>de</strong> Klo<strong>et</strong> editors, Elsevier publisher, vol. 1, 584-<br />

594.<br />

Sahly I., Fabre V., Vyas S., Mil<strong>et</strong> A., Rouzeau J.D., Hamon M., Lazar M., Tronche F.<br />

5-HT1A-iCre, a new transgenic mouse line for gen<strong>et</strong>ic analyses of the serotonergic pathway.<br />

Mol Cell Neurosci., 2007 36 : 27-35.<br />

M. Turiault, S. Parnau<strong>de</strong>au, A. Mil<strong>et</strong>, R. Parlato, J.D. Rouzeau, M. Lazar and<br />

F. Tronche. Analysis of dopamine transporter gene expression pattern : generation of DATiCre<br />

transgenic mice. FEBS Journal, 2007, 274 : 3568-77.<br />

Sainte-Marie Y., Cat A., Perrier R., Mangin L., Soukaseum C., Peuchmaur M.,<br />

Tronche F., Farman N., Escoub<strong>et</strong> B., Benitah J.P., Jaisser F. Conditional glucocorticoid<br />

receptor expression in the heart induces atrio-ventricular block. FASEB J., 2007, 21(12) :<br />

3133-41.<br />

Engblom D., Kornfeld J.W., Schwake L., Tronche F., Reimann A., Beug H.,<br />

Hennighausen L., Moriggl R., Schütz G.. Direct glucocorticoid receptor-Stat5<br />

interaction in hepatocytes controls body size and maturation-related gene expression. Genes<br />

& Dev., 2007, 21 : 1157-62.<br />

Tuckermann J.P., Kleiman A., Moriggl R., Spanbroek R., Neumann A., Illing A.,<br />

Clausen B.E., Stri<strong>de</strong> B., Forster I., Habenicht A.J., Reichardt H.M., Tronche F.,<br />

Schmid W., Schütz G. Macrophages and neutrophils are the targ<strong>et</strong>s for immune suppression<br />

by glucocorticoids in contact allergy. J. Clin. Invest., 2007, 117 : 1381-1390.<br />

Lemberger T., Parlato R., Dassesse D., Westphal M., Casanova E., Turiault M.,<br />

Tronche F., Schiffmann S.N., Schütz G. Expression of Cre recombinase in<br />

dopaminoceptive neurons. BMC Neurosci., 2007, 3 ; 8 : 4.<br />

Muller O., Pra<strong>de</strong>rvand S., Berger S., Centeno G., Mil<strong>et</strong> A., Nicod P.,<br />

Pedrazzini T., Tronche F., Schütz G., Chien K., Rossier B.C., Firsov D. I<strong>de</strong>ntification<br />

of corticosteroid-regulated genes in cardiomyocytes by serial analysis of gene expression.<br />

Genomics, 2007, 89 : 370-377.

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