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Variation in the ciliary neurotrophic factor<br />

gene and muscle strength in older Caucasian<br />

women.<br />

Arking DE et al.<br />

McKusick-Nathans Institute of Genetic<br />

Medicine, Johns Hopkins University, USA.<br />

BMC Physiol. 2005 Sep 23;5:15.<br />

The relationship between ciliary neurotrophic<br />

factor (CNTF) genotype and motorunit<br />

physiology: preliminary studies.<br />

Conwit RA et al.<br />

National Institute on Neurological Disorders<br />

and Stroke, Rockville, MD 20892, USA.<br />

J Appl Physiol. 2001 Apr;90(4):1205-10.<br />

CNTF genotype is associated with muscular<br />

strength and quality in humans acrossthe<br />

adult age span.<br />

Roth SM et al.<br />

Department of Kinesiology, College of Health<br />

and Human Performance, University of<br />

Maryland,USA.<br />

242<br />

握力<br />

●対象者<br />

人種:白人<br />

特徴:地域在住の 70-79 歳の老人女<br />

性<br />

人数:363 名<br />

●評価方法<br />

体内の筋肉における筋繊維の表出と<br />

その発動頻度<br />

●対象者<br />

人種:アメリカ人<br />

特徴:23-94 歳までの健常者<br />

人数:69 名<br />

●評価方法<br />

膝屈筋及び膝伸筋における等張性<br />

収縮(短縮性収縮&伸張性収縮)の<br />

力(トルク)<br />

●対象者<br />

人種:白人 413 名、アフリカ系アメリカ<br />

人63名、その他18名<br />

特徴:20-90 歳の健常人<br />

人数:494 名<br />

SNP のハプロタイプにおい<br />

て関連性を評価すると、当<br />

多型と相関するハプロタイ<br />

プでのみ有意な結果となっ<br />

た(P

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