Stand der Ursachen - Mitteldeutsche Psychiatrietage 2011
Stand der Ursachen - Mitteldeutsche Psychiatrietage 2011
Stand der Ursachen - Mitteldeutsche Psychiatrietage 2011
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Poster | Schizophrenie<br />
P09<br />
Increased radial diffusivity and decreased activation in association with decision<br />
making un<strong>der</strong> uncertainty in schizophrenia: A combined fMRI–DTI study<br />
K. Koch, Jena<br />
Background: The disor<strong>der</strong> of schizophrenia is associated with often widespread changes in white matter<br />
structure. Most studies investigated changes in fractional anisotropy (FA) while alterations in radial or axial<br />
diffusivity have barely been investigated until now. The present study aimed at investigating radial<br />
diffusivity as a potential marker of dysmyelination in direct relation to abnormalities in neural activation.<br />
Methods: Neural activation in association with decision making un<strong>der</strong> uncertainty was investigated in<br />
schizophrenia patients and linked to radial diffusivity as measured by DTI.<br />
Results: Decision making un<strong>der</strong> uncertainty was associated with a significantly decreased activation in a<br />
fronto-striato-cingulate network in patients. Structurally, patients exhibited increased radial diffusivity in<br />
temporal white matter which was negatively correlated with activation in parts of the fronto-striatocingulate<br />
network.<br />
Conclusions: Present d ata indicate that altered diffusivity within relevant white matter networks may be<br />
closely linked to abnormal neural activation in schizophrenia.<br />
8. <strong>Mitteldeutsche</strong> <strong>Psychiatrietage</strong> | 71
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