Stand der Ursachen - Mitteldeutsche Psychiatrietage 2011

Poster | Affektive Störungen
P20
Multimodal integration of graph analytic metrics in Major Depressive Disorder
D. Horn, A. Lord, J. Kaufmann, K. Schiltz, B. Bogerts, J. Steiner, M. Breakspear, M. Walter,
Magdeburg
Background: Whereas region-to-region disturbances of functional connectivity have been documented in
depression large-scale topological changes in fMRI functional connectivity have not been elucidated. The
objectives of our study were to compare graph theoretical networks between patients and controls and to
integrate these with modalities characterizing metabolic dysfunction and behavioral changes.
Methods: Resting state fMRI data were acquired from 22 depressed patients and 22 matched healthy
controls. We characterized graph metrics of the weighted, undirected functional connectivity matrices,
examining integration and segregation at both the whole brain and regional scale. We also studied the
correlation between these measures and the results of MR spectroscopy.
Results: We found no significant differences between groups for global graph metrics. However we did
observe a significant decrease in the betweenness centrality of the right medial temporal gyrus (MTG)
(p=0.033, FDR-corrected) in depression. We also observe a correlation of Glx (combination of
Glutamate/Glutamine) in dorsal anterior cingulate cortex with the local connection strength of the right
supramarginal gyrus (p