o_1977r8vv9vk1ts2ms0kd8pksa.pdf

164 D. Ley, K. MarsÏ—l
Table 12.1. Intrauterine blood flow and postnatal neurodevelopment. ADHD attention deficit hyperactivity disorder, AEDF absent end-diastolic flow, AGA appropriate-forgestational
age, AREDF absent or reverse end-diastolic flow, BFC blood flow class, CI confidence interval, C/P ratio cerebroplacental ratio =ratio between the middle cerebral
artery and umbilical artery PI, c.s. cesarean section, EDF end-diastolic flow, GA gestational age, IUGR intrauterine growth restriction, PI pulsatility index, REDF reverse enddiastolic
flow, RI resistance index, RR risk ratio, S/D systolic-to-diastolic ratio, UA umbilical artery, U/C PI ratio ratio between the umbilical artery and middle cerebral artery PI,
vag. vaginal delivery
Study Study group Control group Follow-up study
Age Test Finding in the study group
Reference Number Doppler
finding
GA at birth
(weeks)
Number Doppler
finding
GA at birth
(weeks)
Umbilical artery
[46] 37 AREDF 26±40 37 Normal RI 32.4 (3.3) Up to 6 months Neurology at discharge More infants with abnormal neurological
evaluation
[48] 25 Abnormal
S/D, c.s.
[49] 7 Abnormal
PI
< 34 17 Normal
S/D, c.s.
40 Preterm,
vag.
< 34 2 years Denver a Poor cognitive progress,
< 34 Bayley b delayed motor development
67 Term, vag. >37
32.1 23 Normal 36.6 4±6 years Neurological exam No significant differences
10 AREDF (3.4) (2.5) Denver a
[47] 20 AREDF ~31 26 Positive
EDF
~33 1±2 years Uzgiris and Hunt c
Militerni d
Greater risk of permanent neurological
sequelae
Bottos e
[50] 31 AEDF < 34 (?) 95 Positive
EDF
[39] 16 AREDF 27 16 Matched
controls
(AGA)
[46] 23 AREDF 28±40 23 Matched
controls
< 34 (?) Every 6 months
up to 4 years
Amiel-Tisson f
Griffith g
No differences in the developmental
quotients or motor outcomes;
Snijders-Oomen h at 2 years lower performance subscale
test
Increased risk for mental retardation and
27 13±91 months Lietz i
Bayley b
Kaufman j
severe motor impairment
28±40 6 years Kaufman j
(3±8.5 years)
Long-term impairment of intellectual development
and partial neurodevelopmental
delay
test l
Man-Drawing test k
Zurich Neuromotor
[60] 27
9
AEDF
REDF
27±37
27±32
40 Positive
EDF
26±38 5±12 years BAS-II m
QNST-II n
SDQ o
Educational achievement
Visual function, hearing
AEDF ± not associated with adverse neurodevelopmental
outcome;
REDF ± associated with a wide range of
problems