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246 E.R. Guzman et al.<br />

Table 16.6. Pregnancy outcomes in placebo and aspirin groups<br />

Parameter Placebo group Aspirin group 95%<br />

CL (%)<br />

p<br />

Hypertension (no.)<br />

Pregnancy-induced 13 (25%) 6 (13%) ±3 to 28 NS<br />

Proteinuric 10 (19%) 1 (2%) 6 to 29 < 0.02<br />

Onset before 37 weeks 9 (17%) 0 7 to 27 < 0.01<br />

Gestation at delivery (weeks) a 38.7Ô3.9 39.5Ô2.1 ± NS<br />

Birth weight (g) a 2,954Ô852 3,068 Ô555 ± NS<br />

3.3 or<br />

n S/D >3.0 with<br />

ipsilateral diastolic<br />

notch<br />

Population n Aspirin Outcomes<br />

dose/timing<br />

CLASP trial<br />

subset<br />

60 60 mg/day<br />

24 weeks<br />

Nulliparous 100 100 mg/day<br />

24 weeks<br />

20 weeks n RI>50% (0.55)<br />

with bilateral<br />

diastolic notch or<br />

n RI>90% (0.65)<br />

with unilateral<br />

notch or<br />

n RI>95% (0.70)<br />

with no notch<br />

Unselected 113 100 mg/day<br />

20 weeks<br />

Preeclampsia<br />

Severe<br />

preeclampsia<br />

Aspirin<br />

(%)<br />

29<br />

13<br />

Placebo<br />

(%)<br />

41<br />

38<br />

Sig.<br />

IUGR (

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