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a Chapter 15 Pulsed Doppler Ultrasonography of the Human Fetal Renal Artery 223<br />

renal artery at the renal hilus and just below the tricuspid<br />

and mitral valves. Fetuses with idiopathic<br />

polyhydramnios had reduced total cardiac output,<br />

decreased right ventricular output, decreased renal<br />

blood flow, decreased renal diameter and decreased<br />

percent renal perfusion compared to euhydramnic<br />

control fetuses [71]. They suggested that in fetuses<br />

with polyhydramnios, renal perfusion was not the<br />

primary cause for the polyhydramnios.<br />

In summary, with the improvements in ultrasound<br />

techniques, color PW Doppler ultrasonography can<br />

be applied to qualify and quantify fetal regional<br />

blood flow in normal and abnormal human fetuses.<br />

These noninvasive methods may reveal how fetal renal<br />

blood flow is affected in fetuses with growth abnormalities,<br />

certain renal diseases, or oligohydramnios<br />

or during maternal intake of certain medications.<br />

A complete understanding of the distribution<br />

of renal blood flow in fetuses at risk for asymmetric<br />

IUGR may lead to an earlier diagnosis of such pathologic<br />

conditions, which may permit early intervention.<br />

Such intervention may then decrease the morbidity<br />

and mortality associated with IUGR fetuses.<br />

References<br />

1. Kremkau F (1993) Diagnostic ultrasound, principles<br />

and instruments. Saunders, Philadelphia<br />

2. FitzGerald DE, Drumm JE (1977) Non-invasive measurement<br />

of human umbilical arteries after delivery.<br />

BMJ 2:1450±1451<br />

3. McCallum WD, Williams CS, Napel S, Daigle RE (1978)<br />

Fetal blood velocity waveforms. Am J Obstet Gynecol<br />

132:425±429<br />

4. Maulik D, Saini VD, Nanda NC, Rosenzweig MS (1982)<br />

Doppler evaluation of fetal hemodynamics. Ultrasound<br />

Med Biol 8:705±710<br />

5. Trudinger BJ, Giles WB, Cook CM (1985) Flow velocity<br />

waveforms in the maternal uteroplacental and fetal umbilical<br />

circulations. Am J Obstet Gynecol 152:155±163<br />

6. Eik-Nes SH, Brubakk AO, Ulstein M (1980) Measurement<br />

of human fetal blood flow. BMJ 1:283±284<br />

7. Shulman H, Fleisher A, Stern W et al. (1984) Umbilical<br />

velocity wave ratios in human pregnancy. Am J Obstet<br />

Gynecol 148:985±990<br />

8. Pearce JM, Campbell S, Cohen-Overbeek TA et al.<br />

(1988) References, ranges, and sources of variation for<br />

indices of pulsed Doppler flow velocity waveforms<br />

from the uteroplacental and fetal circulation. Br J Obstet<br />

Gynaecol 95:248±256<br />

9. Reed KL, Meijboom EJ, Sahn DJ et al. (1986) Cardiac<br />

Doppler flow velocities in human fetuses. Circulation<br />

73:41±46<br />

10. Campbell S, Vyas S (1988) Color flow mapping in measurements<br />

of flow velocity in fetal renal arteries. Presented<br />

at the First International Meeting: Fetal and<br />

Neonatal Color Flow Mapping, Dubrovnik<br />

11. Vyas S, Nicolaides KH, Campbell S (1989) Renal artery<br />

flow velocity waveforms in normal and hypoxemic fetuses.<br />

Am J Obstet Gynecol 161:168±172<br />

12. Hecher K, Spernol R, Szalay S (1989) Doppler blood<br />

flow velocity waveforms in the fetal renal artery. Arch<br />

Gynecol Obstet 246:133±137<br />

13. Veille JC, Kanaan C (1989) Duplex Doppler ultrasonographic<br />

evaluation of the fetal renal artery in normal<br />

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1507<br />

14. Maeda K, Takeuchi Y (1990) Fetal renal arterial blood<br />

velocity waveforms detected with color-flow mapping<br />

and pulsed Doppler flowmetry in intrauterine growht<br />

retardation. J Clin Ultrasound 18:527±531<br />

15. Vyas S, Campbell S (1992) Doppler studies of the cerebral<br />

and renal circulations in small-for-gestational age<br />

fetuses. In: Pearce JM (ed) Doppler ultrasound in perinatal<br />

medicine. Oxford University Press, New York,<br />

pp 268±278<br />

16. Arduini D, Rizzo G (1991) Fetal renal artery velocity<br />

waveforms and amniotic fluid volume in growth-retarded<br />

and post-term fetuses. Obstet Gynecol 77:370±<br />

373<br />

17. Mari G, Kirshon B, Abuhamad A (1993) Fetal renal artery<br />

flow velocity waveforms in normal pregnancies<br />

and pregnancies complicated by polyhydramnios and<br />

oligohydramnios. Obstet Gynecol 81:560±564<br />

18. Stuart B, Drum J, FitzGerald DE, Duignan NM (1988)<br />

Fetal blood flow velocity wveforms in normal pregnancy.<br />

Br J Obstet Gynecol 87:780±785<br />

19. Fong K, Ryan ML, Cohen H, Amankwah K, Ohlsson A,<br />

Myhr T, Hannah M (1996) Doppler velocimetry of the<br />

fetal middle cerebral and renal arteries: interobserver<br />

reliability. J Ultrasound Med 15:317±321<br />

20. Veille JC, Hanson R, MacNeil S, Kelley K (1993) Quantitative<br />

assessment of human fetal kidney blood flow.<br />

Am J Obstet Gynecol 169:1399±1402<br />

21. Joern H, Funk A, Goetz M, Kuehlwein H, Klein A, Fendel<br />

H (1996) Development of quantitative Doppler indices<br />

for uteroplacental and fetal blood flow during the<br />

third trimester. Ultrasound Med Biol 22:823±835<br />

22. Veille JC, McNeil S, Hanson R, Smith N (1998) Renal<br />

Hemodynamics: Longitudinal Study from the Late Fetal<br />

Life to One Year of Age. J Maternal Fetal Investigation<br />

8:6±10<br />

23. Konje JC, Abrahms K, Bell SC, de Chazal RC, Taylor DJ<br />

(2000) The application of color power angiography to<br />

the longitudinal quantification of blood flow volume in<br />

the fetal middle cerebral arteries, ascending aorta, descending<br />

aorta, and renal arteries during gestation. Am<br />

J Obstet Gynecol 182:393±400<br />

24. Andriani G, Persico A, Tursini S, Ballone E, Cirotti D,<br />

Lelli Chiesa P (2001) The renal-resistive index from the<br />

last 3 months of pregnancy to 6 months old. BJU Int<br />

87:562±564<br />

25. Yasuhi I, Hirai M, Oka S, Nakajima H, Ishimaru T<br />

(1997) Effect of maternal meal ingestion on fetal renal<br />

artery resistance. Obstet Gynecol 90(3):340±343<br />

26. Stigter RH, Mulder EJ, Bruinse HW, Visser GH (2001)<br />

Doppler studies on the fetal renal artery in the severely<br />

growth-restricted fetus. Ultrasound Obstet Gynecol<br />

141±145<br />

27. Bates JA, Evans JA, Mason G (1997) Differentiation of<br />

growth retarded from normally grown fetuses and prediction<br />

of intrauterine growth retardation using Doppler<br />

ultrasound. Br J Obstet Gynaecol 104:121

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