ENVIRONMENT, hOUSING, ANd MANAGEMENT3Georgsson L, Barrett J, Gietzen D. 2001. The effects <strong>of</strong> group-housing <strong>and</strong> relative weight onfeeding behaviour in rats. Sc<strong>and</strong> J Lab Anim Sci 28:201-209.Gibson SV, Besch-Willi<strong>for</strong>d C, Raisbeck MF, Wagner JE, McLaughlin RM. 1987. Organophosphatetoxicity in rats associated with contaminated bedding. Lab Anim 37:789-791.Gill TJ. 1980. The use <strong>of</strong> r<strong>and</strong>omly bred <strong>and</strong> genetically defined animals in biomedical research.Am J Pathol 101(3S):S21-S32.Godfrey EW, S<strong>and</strong>ers GW. 2004. Effect <strong>of</strong> water hardness on oocyte quality <strong>and</strong> embryo developmentin <strong>the</strong> African clawed frog (Xenopus laeis). Comp Med 54:170-175.Gonder JC, Laber K. 2007. A renewed look at laboratory rodent housing <strong>and</strong> management.ILAR J 48:29-36.Gonzalez RR, Kiuger MJ, Hardy JD. 1971. Partitional calorimetry <strong>of</strong> <strong>the</strong> New Zeal<strong>and</strong> whiterabbit at temperatures <strong>of</strong> 5-35°C. J Appl Physiol 31:728.Gordon AH, Hart PD, Young MR. 1980. Ammonia inhibits phagosome-lysosome fusion inmacrophages. Nature 286:79-80.Gordon CJ. 1990. Thermal biology <strong>of</strong> <strong>the</strong> laboratory rat. Physiol Behav 47:963-991.Gordon CJ. 1993. Temperature Regulation in <strong>Laboratory</strong> <strong>Animals</strong>. New York: CambridgeUniversity Press.Gordon CJ. 2004. Effect <strong>of</strong> cage bedding on temperature regulation <strong>and</strong> metabolism <strong>of</strong> grouphousedfemale mice. Comp Med 54:63-68.Gordon CJ. 2005. Temperature <strong>and</strong> Toxicology: An integrative, comparative <strong>and</strong> environmentalapproach. Boca Raton, FL: CRC Press.Gordon CJ, Becker P, Ali JS. 1998. Behavioral <strong>the</strong>rmoregulatory responses <strong>of</strong> single- <strong>and</strong> grouphousedmice. Physiol Behav 65:255-262.Green EL. 1981. Genetics <strong>and</strong> Probability in Animal Breeding Experiments. New York: Ox<strong>for</strong>dUniversity Press.Green SL. 2002. Factors affecting oogenesis in <strong>the</strong> South African clawed frog (Xenopus laeis).Comp Med 52:307-312.Green SL. 2009. The <strong>Laboratory</strong> Xenopus sp. (<strong>Laboratory</strong> Animal Pocket Reference). BocaRaton, FL: CRC Press.Greenman DL, Bryant P, Kodell RL, Sheldon W. 1982. Influence <strong>of</strong> cage shelf level on retinalatrophy in mice. Lab Anim Sci 32:353-356.Gresens J. 2004. An introduction to <strong>the</strong> Mexican axolotl (Ambystoma mexicanum). Lab Anim33:41-47.Groen A. 1977. Identification <strong>and</strong> genetic monitoring <strong>of</strong> mouse inbred strains using biomedicalpolymorphisms. Lab Anim (London) II:209-214.Gunasekara AS, Rubin AL, Goh KS, Spurlock FC, Tjeerdema RS. 2008. Environmental fate <strong>and</strong>toxicology <strong>of</strong> carbaryl. Rev Environ Contam Toxicol 196:95-121.Gutleb AC, Bronkhorst M, van den Berg JHJ, Musrk AJ. 2001. Latex laboratory gloves: Anunexpected pitfall in amphibian toxicity assays with tadpoles. Environ Toxicol Pharmacol10:119-121.Haemisch A, Voss T, Gärtner K. 1994 Effects <strong>of</strong> environmental enrichment on aggressivebehaviour, dominance hierarchies <strong>and</strong> endocrine states in male DBA/2J mice. PhysiolBehav 56:1041-1048.Hahn NE, Lau D, Eckert K, Markowitz H. 2000. Environmental enrichment-related injury in amacaque (Macaca fascicularis): Intestinal linear <strong>for</strong>eign body. Comp Med 50:556-558.Hall FS. 1998. Social deprivation <strong>of</strong> neonatal, adolescent, <strong>and</strong> adult rats has distinct neurochemical<strong>and</strong> behavioural consequences. Crit Rev Neurobiol 12:129-162.Hall JE, White WJ, Lang CM. 1980. Acidification <strong>of</strong> drinking water: Its effects on selectedbiologic phenomena in male mice. Lab Anim Sci 30:643-651.
4GUIdE FOR ThE CARE ANd USE OF LAbORATORy ANIMALSHankenson FC, Garzel LM, Fischer DD, Nolan B, Hankenson KD. 2008. Evaluation <strong>of</strong> tail biopsycollection in laboratory mice (Mus musculus): Vertebral ossification, DNA quantity,<strong>and</strong> acute behavioral responses. JAALAS 47(6):10-18.Hanifin JP, Brainard GC. 2007. Photoreception <strong>for</strong> circadian, neuroendocrine, <strong>and</strong> neurobehavioralregulation. J Physiol Anthropol 26:87-94.Hartl DL. 2000. A Primer <strong>of</strong> Population Genetics, 3rd ed. Sunderl<strong>and</strong>, MA: Sinauer Associates.Hasenau JJ, Baggs RB, Kraus AL. 1993. Microenvironments in microisolation cages usingBALB/c <strong>and</strong> CD-1 Mice. Contemp Top Lab Anim Sci 32:11-16.Hedrich HJ. 1990. Genetic Monitoring <strong>of</strong> Inbred Strains <strong>of</strong> Rats. New York: Gustav FischerVerlag.Heffner HE, Heffner RS. 2007. Hearing ranges <strong>of</strong> laboratory animals. JAALAS 46:20-22.Held SDE, Turner RJ, Wootton RJ. 1995. Choices <strong>of</strong> laboratory rabbits <strong>for</strong> individual or grouphousing.Appl Anim Behav Sci 46:81-91Hermann LM, White WJ, Lang CM. 1982. Prolonged exposure to acid, chlorine, or tetracyclinein drinking water: Effects on delayed-type hypersensitivity, hemagglutination titers, <strong>and</strong>reticuloendo<strong>the</strong>lial clearance rates in mice. Lab Anim Sci 32:603-608.Hess SE, Rohr S, Dufour BD, Gaskill BN, Pajor EA, Garner JP. 2008. Home improvement:C57BL/6J mice given more naturalistic nesting materials build better nests. JAALAS47:25-31.Hilken G, Dimigen J, Iglauer F. 1995. Growth <strong>of</strong> Xenopus laeis under different laboratoryrearing conditions. Lab Anim 29:152-162.Hill D. 1999. Safe h<strong>and</strong>ling <strong>and</strong> disposal <strong>of</strong> laboratory animal waste. Occup Med14:449-468.H<strong>of</strong>fman HA, Smith KT, Crowell JS, Nomura T, Tomita T. 1980. Genetic quality control <strong>of</strong>laboratory animals with emphasis on genetic monitoring. In: Spiegel A, Erichsen S, SolleveldHA, eds. Animal Quality <strong>and</strong> Models in Biomedical Research. Stuttgart: GustavFischer Verlag. p 307-317.Homberger FR, Pataki Z, Thomann PE. 1993. Control <strong>of</strong> Pseudomonas aeruginosa infection inmice by chlorine treatment <strong>of</strong> drinking water. Lab Anim Sci 43:635-637.Hotchkiss CE, Paule MG. 2003. Effect <strong>of</strong> pair-housing on operant behavior task per<strong>for</strong>manceby rhesus monkeys. Contemp Top Lab Anim Sci 42:38-41.Hubrecht RC. 1993. A comparison <strong>of</strong> social <strong>and</strong> environmental enrichment methods <strong>for</strong> laboratoryhoused dogs. Appl Anim Behav Sci 37:345-361.Hughes HC, Reynolds S. 1995. The use <strong>of</strong> computational fluid dynamics <strong>for</strong> modeling air flowdesign in a kennel facility. Contemp Top Lab Anim Sci 34:49-53Ikemoto S, Panksepp J. 1992. The effect <strong>of</strong> early social isolation on <strong>the</strong> motivation <strong>for</strong> socialplay in juvenile rats. Dev Psychobiol 25:261-274.Ivy AS, Brunson KL, S<strong>and</strong>man C, Baram TZ. 2008. Dysfunctional nurturing behavior in ratdams with limited access to nesting material: A clinically relevant model <strong>for</strong> early-lifestress. Neuroscience 154:1132-1142.Jacobs BB, Dieter DK. 1978. Spontaneous hepatomas in mice inbred from Ha:ICR Swiss stock:Effects <strong>of</strong> sex, cedar shavings in bedding, <strong>and</strong> immunization with fetal liver or hepatomacells. J Natl Cancer Inst 61:1531-1534.Jones DM. 1977. The occurrence <strong>of</strong> dieldrin in sawdust used as bedding material. Lab Anim11:137.Karolewicz B, Paul IA. 2001. Group housing <strong>of</strong> mice increases immobility <strong>and</strong> antidepressantsensitivity in <strong>the</strong> <strong>for</strong>ced swim <strong>and</strong> tail suspension tests. Eur J Pharmacol 415:97-201.Kaufman BM, Pouliot AL, Tiefenbacher S, Novak MA. 2004. Short- <strong>and</strong> long-term effects <strong>of</strong>a substantial change in cage size on individually housed, adult male rhesus monkeys(Macaca mulatta). Appl Anim Behav Sci 88:319-330.
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The National Academy of Sciences is
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xiiiOVERVIEWing the growing role of
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appendixDAbout the AuthorsJanet C.
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IndexAAcclimation and adaptation, 1
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INdEX 211Behavioral and social mana
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INdEX 213Disinfection, 20, 51, 52,
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INdEX 215Hydrogen peroxide, 72Hygie
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INdEXrecommended reading, 169-170re
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INdEX21pain and distress, 121-122re
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