Guide for the Care and Use of Laboratory Animals - Office of ...

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CONTENTSxxiiiAquatic Management, 84Behavior and Social Management, 84Husbandry, 84Population Management, 87References, 884 VETERINARy CARE 105Animal Procurement and Transportation, 106Animal Procurement, 106Transportation of Animals, 107Preventive Medicine, 109Animal Biosecurity, 109Quarantine and Stabilization, 110Separation by Health Status and Species, 111Surveillance, Diagnosis, Treatment, and Control of Disease, 112Clinical Care and Management, 113Medical Management, 114Emergency Care, 114Recordkeeping, 115Surgery, 115Training, 115Presurgical Planning, 116Surgical Facilities, 116Surgical Procedures, 117Aseptic Technique, 118Intraoperative Monitoring, 119Postoperative Care, 119Pain and Distress, 120Anesthesia and Analgesia, 121Euthanasia, 123References, 1245 PHySICAL PLANT 133General Considerations, 133Location, 134Centralization Versus Decentralization, 134Functional Areas, 135Construction Guidelines, 136Corridors, 136Animal Room Doors, 137Exterior Windows, 137Floors, 137
xxiCONTENTSDrainage, 138Walls and Ceilings, 138Heating, Ventilation, and Air Conditioning (HVAC), 139Power and Lighting, 141Storage Areas, 141Noise Control, 142Vibration Control, 142Facilities for Sanitizing Materials, 143Environmental Monitoring, 143Special Facilities, 144Surgery, 144Barrier Facilities, 145Imaging, 146Whole Body Irradiation, 147Hazardous Agent Containment, 148Behavioral Studies, 149Aquatic Species Housing, 150Security and Access Control, 151References, 151ADDENDUM 155APPENDICESA ADDITIONAL SELECTED REFERENCES 161Subject Matter, 161Use of Laboratory Animals, 162Alternatives, 162Ethics and Welfare, 163Experimental Design and Statistics, 164Research and Testing Methodology, 165Program Management, 167General References, 167Laws, Regulations, and Policies, 168Education, 169Monitoring the Care and Use of Animals, 169Occupational Health and Safety, 170Environment, Housing, and Management, 172General References, 172Environmental Enrichment, 173Genetics and Genetically Modified Animals, 175
Page 2 and 3: GUIDEFOR THE CARE AND USE OFLABORAT
Page 4: The National Academy of Sciences is
Page 7 and 8: MembersINSTITUTE FOR LAbORATORy ANI
Page 9 and 10: INSTITUTE FOR LAbORATORy ANIMAL RES
Page 12 and 13: ReviewersThis eighth edition of the
Page 14 and 15: PrefaceThe purpose of the Guide for
Page 16: PREFACExwho soon recognized that th
Page 19 and 20: xiiiOVERVIEWing the growing role of
Page 22 and 23: Contents1 KEy CONCEPTS 1Applicabili
Page 26: CONTENTSxxSpecies-Specific Referenc
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Page 38 and 39: 2Animal Care and Use ProgramThe pro
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Page 68 and 69: 3Environment, Housing,and Managemen
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4Veterinary CareVeterinary care is
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VETERINARy CARE10from these sources
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VETERINARy CARE10In all cases, appr
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VETERINARy CARE 111Depending on the
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VETERINARy CARE 113and serology. If
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VETERINARy CARE 115RecordkeepingMed
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VETERINARy CARE11traffic (AORN 2006
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VETERINARy CARE11Specific steriliza
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VETERINARy CARE 121(all), anorexia
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VETERINARy CARE 123used in combinat
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VETERINARy CARE 125Arndt SS, Lohave
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VETERINARy CARE12Haines DC, Gorelic
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VETERINARy CARE12Morton CM, Reid J,
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VETERINARy CARE 131Stoskopf MK. 199
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Appendices
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appendixBU.S. Government Principles
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appendixCStatement of TaskThe use o
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appendixDAbout the AuthorsJanet C.
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APPENdIX d: AbOUT ThE AUThORS 205of
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APPENdIX d: AbOUT ThE AUThORS20Amer
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IndexAAcclimation and adaptation, 1
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INdEX 211Behavioral and social mana
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INdEX 213Disinfection, 20, 51, 52,
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INdEX 215Hydrogen peroxide, 72Hygie
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INdEXrecommended reading, 169-170re
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INdEX21pain and distress, 121-122re
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