Guide for the Care and Use of Laboratory Animals - Office of ...

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Contents1 KEy CONCEPTS 1Applicability and Goals, 2Intended Audiences and Uses of the Guide, 3Ethics and Animal Use, 4The Three Rs, 4Key Terms Used in the Guide, 5Humane Care, 6Animal Care and Use Program, 6Engineering, Performance, and Practice Standards, 6Policies, Principles, and Procedures, 7Must, Should, and May, 8References, 82 ANIMAL CARE AND USE PROGRAM 11Regulations, Policies, and Principles, 12Program Management, 13Program Management Responsibility, 13The Institutional Official, 13The Attending Veterinarian, 14The Institutional Animal Care and Use Committee, 14Collaborations, 15Personnel Management, 15Training and Education, 15Occupational Health and Safety of Personnel, 17xxi
xxiiCONTENTSPersonnel Security, 23Investigating and Reporting Animal Welfare Concerns, 23Program Oversight, 24The Role of the IACUC, 24IACUC Constitution and Function, 24Protocol Review, 25Special Considerations for IACUC Review, 27Postapproval Monitoring, 33Disaster Planning and Emergency Preparedness, 35References, 353 ENVIRONMENT, HOUSING, AND MANAGEMENT 41Terrestrial Animals, 42Terrestrial Environment, 42Microenvironment and Macroenvironment, 42Temperature and Humidity, 43Ventilation and Air Quality, 45Illumination, 47Noise and Vibration, 49Terrestrial Housing, 50Microenvironment (Primary Enclosure), 50Environmental Enrichment, 52Sheltered or Outdoor Housing, 54Naturalistic Environments, 55Space, 55Terrestrial Management, 63Behavioral and Social Management, 63Husbandry, 65Population Management, 75Aquatic Animals, 77Aquatic Environment, 77Microenvironment and Macroenvironment, 77Water Quality, 78Life Support System, 79Temperature, Humidity, and Ventilation, 80Illumination, 81Noise and Vibration, 81Aquatic Housing, 82Microenvironment (Primary Enclosure), 82Environmental Enrichment and Social Housing, 82Sheltered, Outdoor, and Naturalistic Housing, 83Space, 83
Page 2 and 3: GUIDEFOR THE CARE AND USE OFLABORAT
Page 4: The National Academy of Sciences is
Page 7 and 8: MembersINSTITUTE FOR LAbORATORy ANI
Page 9 and 10: INSTITUTE FOR LAbORATORy ANIMAL RES
Page 12 and 13: ReviewersThis eighth edition of the
Page 14 and 15: PrefaceThe purpose of the Guide for
Page 16: PREFACExwho soon recognized that th
Page 19 and 20: xiiiOVERVIEWing the growing role of
Page 24 and 25: CONTENTSxxiiiAquatic Management, 84
Page 26: CONTENTSxxSpecies-Specific Referenc
Page 29 and 30: 2 GUIdE FOR ThE CARE ANd USE OF LAb
Page 38 and 39: 2Animal Care and Use ProgramThe pro
Page 40 and 41: ANIMAL CARE ANd USE PROGRAM 13of li
Page 42 and 43: ANIMAL CARE ANd USE PROGRAM 15ers a
Page 44 and 45: ANIMAL CARE ANd USE PROGRAM1used (C
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Page 54 and 55: ANIMAL CARE ANd USE PROGRAM2Special
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Page 58 and 59: ANIMAL CARE ANd USE PROGRAM 31least
Page 60 and 61: ANIMAL CARE ANd USE PROGRAM 33disea
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Page 68 and 69: 3Environment, Housing,and Managemen
Page 70 and 71: ENVIRONMENT, hOUSING, ANd MANAGEMEN
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4Veterinary CareVeterinary care is
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VETERINARy CARE10from these sources
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VETERINARy CARE10In all cases, appr
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VETERINARy CARE 111Depending on the
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VETERINARy CARE 113and serology. If
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VETERINARy CARE 115RecordkeepingMed
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VETERINARy CARE11traffic (AORN 2006
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VETERINARy CARE11Specific steriliza
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VETERINARy CARE 121(all), anorexia
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VETERINARy CARE 123used in combinat
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VETERINARy CARE 125Arndt SS, Lohave
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VETERINARy CARE12Haines DC, Gorelic
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VETERINARy CARE12Morton CM, Reid J,
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VETERINARy CARE 131Stoskopf MK. 199
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156 AddENdUM4. Page 32. Original se
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Appendices
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appendixBU.S. Government Principles
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appendixCStatement of TaskThe use o
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appendixDAbout the AuthorsJanet C.
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APPENdIX d: AbOUT ThE AUThORS 205of
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APPENdIX d: AbOUT ThE AUThORS20Amer
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IndexAAcclimation and adaptation, 1
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INdEX 211Behavioral and social mana
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INdEX 213Disinfection, 20, 51, 52,
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INdEX 215Hydrogen peroxide, 72Hygie
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INdEXrecommended reading, 169-170re
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INdEX21pain and distress, 121-122re
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