Guide for the Care and Use of Laboratory Animals - Office of ...

216 INdEXMicroenvironment (primary enclosure)aquatic species, 77-78, 82-83defined, 42terrestrial species, 42, 50-52Midwest Plan Service, 33Monitoring and surveillancedisease prevention, 112-113facilities, equipment, and exposure, 19-20food and fluid intake, 31GMAs, 28intraoperative, 119postapproval, 33-34postoperative care, 119restrained animals, 29sanitation practices, 72-73Monkeys (see Nonhuman primates)Monoclonal antibody production, 27Moribund state, 28Mouse hepatitis virus, 112, 113Mycoplasma hyopneumoniae, 112NNational Institutes of Health, 19, 155National Research Council Committee onAnimal Nutrition, 65Necropsies, 21Nesting (see Bedding, nesting, andsubstrates)Neuromuscular blocking agents, 122-123Nocturnal animals, 48Noise and vibrationaquatic animals, 81-82control, 142, 143hearing protection for personnel, 22, 49terrestrial animals, 49-50Non-pharmaceutical-grade chemicals orsubstances, 31-32Nonhuman primatesacclimation, 111behavioral and social management, xviii,29, 53enrichment, 53, 67, 137environment, 43, 44, 45, 50, 139food and feeding, 67housing, xviii, 49, 111-112, 136illumination, 48infections, 23, 111-112infusion pumps, 29noise and vibration effects, 50personal protective equipment for staff,21-22recommended reading, 182-184, 194recordkeeping, 75-76restraint, 29space requirements, xviii, 56, 58-60, 61temperature and humidity, 43, 44, 45,140transport, 107ventilation, 47, 139veterinary care, 194zoonosis surveillance and, 23, 110Noroviruses, 113OOccupational health and safety programadministrative controls, 18animal housing systems, 19-20collaborative approach, 17, 21control and prevention strategies, 18engineering controls, 18, 19facility and equipment support, 19-20field studies or wildlife research, 18hazard identification and riskassessment, 18-19hazardous animal experimentation, 18,20-21hazardous material containment, 149hygiene, 18, 19, 20medical evaluation and preventivemedicine for personnel, 22-23monitoring, 19-20noise exposure, 22, 49personal protective equipment, 18, 20,21, 23, 109, 146, 148, 167-172recommended reading, 17, 19, 21,170-172regulations, 17, 18, 20, 21reporting requirements, 23-24responsibility, 18safety committee, 17-18, 21, 32security, 23training, 17, 18, 20, 21, 22, 24Organ or system failure research, 27Other animals, recommended reading,187-188Outdoor enclosures/habitats, 42, 44, 51,54-55, 68, 74, 81, 83, 118, 134, 135,139, 140Oversight (see also Institutional Animal Careand Use Committee)postapproval monitoring, 33-34