Guide for the Care and Use of Laboratory Animals - Office of ...

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APPENdIX d: AbOUT ThE AUThORS20American Veterinary Medical Association and the American Associationof Veterinary Medical Colleges. Senator Melcher represents the public’sperspective.Fred W. Quimby, VMD, PhD, is a board-certified laboratory animal veterinarian,with a doctorate in pathology, specialized in the assessment ofimmune function in animals. Prior to his retirement in 2007 he was AssociateVice President at Rockefeller University, while over the past 35 years heoversaw the research animal programs at three Universities (Tufts, Cornell,and Rockefeller) and held the position of Professor at Cornell’s Colleges ofMedicine and Veterinary Medicine. He conducted research and lectured inthe fields of immunology, pathology and environmental toxicology wherehe focused his research on toxic shock syndrome, environmental intoxicationwith polychlorinated biphenyls (PCBs), and immune dysfunction in petdogs. As a laboratory animal professional he has designed and overseen theconstruction of five animal facilities for research animals and a zoologicalpark. Dr. Quimby has had broad experience with a wide assortment oflaboratory animals including rodents, dogs, primates, livestock, poultry, andfish, and published on the diseases, care, and /or housing of each of them.He has served on various NAS/NRC committees including the Guide committee,the Committee on Immunologically Compromised Rodents (Chair),the Transgenic Animal Committee, the Committee to Develop Standardsfor Dogs (Chair), the Monoclonal Antibody Production Committee, andthe Committee Evaluating Increasing Veterinary Involvement in BiomedicalResearch. He served as a member of the ILAR Council and chaired theEditorial Committee of the ILAR News. He is currently serving as a memberof the Committee to Assess the Current and Future Workforce Needs in VeterinaryMedicine. He was a charter member of the Society for VeterinaryEthics, a member of the Board of Directors for the National Association forBiomedical Research and a member of the Strategic Planning Committeefor AAALAC International.Patricia V. Turner, MS, DVM, DVSc, is Associate Professor and ProgramLeader of Laboratory Animal Science in the Department of Pathobiologyat the University of Guelph, Canada, where she also is currentlyChair of the Animal Care Committee. She has a doctorate in comparativepathology and is a Diplomate of both the American College of LaboratoryAnimal Medicine and the American Board of Toxicology. Dr. Turner hasexperience managing Canadian Council of Animal Care–compliant animalfacilities that house a full range of species (fish, rodents and rabbits,dogs and cats, swine and sheep, nonhuman primates) in both academicand industry (GLP) settings. Dr. Turner serves as an AAALAC internationalad hoc specialist with excellent knowledge of current US guidelines and
208 GUIdE FOR ThE CARE ANd USE OF LAbORATORy ANIMALSregulations concerning research animal care and use. Her research interestsinclude innate immunity and infectious disease, toxicologic pathology, andthe interactions between rodents and their environment as they relate todisease susceptibility. In 2007 she was the inaugural recipient of the NorthAmerican Animal Welfare Award, co-sponsored by Procter & Gamble andthe Humane Society of the United States.Geoffrey A. Wood, DVM, PhD, DVSc, is Associate Professor in the Departmentof Pathobiology at the Ontario Veterinary College, University ofGuelph, Canada. Dr. Wood has a doctorate in cancer biology and a doctoratein veterinary pathology. He has been involved in design or pathologiccharacterization of hundreds of genetically engineered rodents, both as theformer Associate Director of Pathology at the Centre for Modeling HumanDisease in Toronto, and in his current position. His lab conducts researchon cancer genetics and the process of metastasis, with a focus on bone andprostate cancer. Dr. Wood’s research collaborations include projects investigatingvarious aspects of a wide range of different cancer types, as well asstudies on stem cell biology, immunity, and inflammation.Hanno Würbel, Dr.sc.nat, is Professor of Animal Welfare and Ethology atthe Justus Liebig University in Giessen, Germany. He has studied biology(zoology) at the University of Berne, Switzerland and graduated fromthe ETH Zürich, Switzerland with a doctorate in natural sciences. He hasexperience in animal behavior and in the scientific assessment of animalwell-being, and has mostly worked with rodents, but also with rabbits, dogs,poultry, and horses. His research focuses on environment-dependent plasticityof brain and behavior in relation to questions of animal husbandry andanimal welfare. In 2005 Dr. Würbel received the Hessian Animal WelfareResearch Prize and in 2009 the Felix Wankel Animal Welfare ResearchAward. He is a member of the Animal Welfare Council of the Germangovernment, Central Animal Welfare Officer of the University of Giessen,and head of the University’s Central Animal Facility. He is also a councilmember of the International Society of Applied Ethology (ISAE), editor of theJournal of Applied Animal Welfare Science, and editorial board member ofthe journal Applied Animal behaiour Science.
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GUIDEFOR THE CARE AND USE OFLABORAT
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The National Academy of Sciences is
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MembersINSTITUTE FOR LAbORATORy ANI
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INSTITUTE FOR LAbORATORy ANIMAL RES
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ReviewersThis eighth edition of the
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PrefaceThe purpose of the Guide for
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PREFACExwho soon recognized that th
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xiiiOVERVIEWing the growing role of
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Contents1 KEy CONCEPTS 1Applicabili
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CONTENTSxxiiiAquatic Management, 84
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CONTENTSxxSpecies-Specific Referenc
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2 GUIdE FOR ThE CARE ANd USE OF LAb
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2Animal Care and Use ProgramThe pro
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ANIMAL CARE ANd USE PROGRAM 13of li
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ANIMAL CARE ANd USE PROGRAM 15ers a
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ANIMAL CARE ANd USE PROGRAM1used (C
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ANIMAL CARE ANd USE PROGRAM1severit
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ANIMAL CARE ANd USE PROGRAM 21Insti
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ANIMAL CARE ANd USE PROGRAM 23et al
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ANIMAL CARE ANd USE PROGRAM 25compe
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ANIMAL CARE ANd USE PROGRAM2Special
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ANIMAL CARE ANd USE PROGRAM2help to
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ANIMAL CARE ANd USE PROGRAM 31least
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ANIMAL CARE ANd USE PROGRAM 33disea
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ANIMAL CARE ANd USE PROGRAM 35DISAS
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ANIMAL CARE ANd USE PROGRAM3DHHS [D
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ANIMAL CARE ANd USE PROGRAM3Olfert
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3Environment, Housing,and Managemen
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ENVIRONMENT, hOUSING, ANd MANAGEMEN
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4Veterinary CareVeterinary care is
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VETERINARy CARE10from these sources
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VETERINARy CARE10In all cases, appr
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VETERINARy CARE 111Depending on the
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VETERINARy CARE 113and serology. If
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VETERINARy CARE 115RecordkeepingMed
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VETERINARy CARE11traffic (AORN 2006
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VETERINARy CARE11Specific steriliza
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VETERINARy CARE 121(all), anorexia
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VETERINARy CARE 123used in combinat
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VETERINARy CARE 125Arndt SS, Lohave
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VETERINARy CARE12Haines DC, Gorelic
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VETERINARy CARE12Morton CM, Reid J,
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VETERINARy CARE 131Stoskopf MK. 199
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Page 183 and 184: 156 AddENdUM4. Page 32. Original se
Page 186: Appendices
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Page 226 and 227: appendixBU.S. Government Principles
Page 228 and 229: appendixCStatement of TaskThe use o
Page 230 and 231: appendixDAbout the AuthorsJanet C.
Page 232 and 233: APPENdIX d: AbOUT ThE AUThORS 205of
Page 236 and 237: IndexAAcclimation and adaptation, 1
Page 238 and 239: INdEX 211Behavioral and social mana
Page 240 and 241: INdEX 213Disinfection, 20, 51, 52,
Page 242 and 243: INdEX 215Hydrogen peroxide, 72Hygie
Page 244 and 245: INdEXrecommended reading, 169-170re
Page 246 and 247: INdEX21pain and distress, 121-122re
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